دورية أكاديمية
أعرض في EDS

Phospholipase A 2 Drives Tumorigenesis and Cancer Aggressiveness through Its Interaction with Annexin A1.

التفاصيل البيبلوغرافية
العنوان: Phospholipase A 2 Drives Tumorigenesis and Cancer Aggressiveness through Its Interaction with Annexin A1.
المؤلفون: Vecchi L; Laboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil., Araújo TG; Laboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil.; Laboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, Brazil., Azevedo FVPV; Laboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil., Mota STS; Laboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil., Ávila VMR; Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil., Ribeiro MA; Laboratory of Genetics and Biotechnology, Federal University of Uberlandia, Patos de Minas 387400-128, MG, Brazil., Goulart LR; Laboratory of Nanobiotechnology, Federal University of Uberlandia, Uberlandia 38400-902, MG, Brazil.
المصدر: Cells [Cells] 2021 Jun 11; Vol. 10 (6). Date of Electronic Publication: 2021 Jun 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Annexin A1/*metabolism , Carcinogenesis/*pathology , Neoplasms/*pathology , Phospholipases A2/*metabolism, Animals ; Carcinogenesis/metabolism ; Humans ; Neoplasms/metabolism
مستخلص: Phospholipids are suggested to drive tumorigenesis through their essential role in inflammation. Phospholipase A 2 (PLA 2 ) is a phospholipid metabolizing enzyme that releases free fatty acids, mostly arachidonic acid, and lysophospholipids, which contribute to the development of the tumor microenvironment (TME), promoting immune evasion, angiogenesis, tumor growth, and invasiveness. The mechanisms mediated by PLA 2 are not fully understood, especially because an important inhibitory molecule, Annexin A1, is present in the TME but does not exert its action. Here, we will discuss how Annexin A1 in cancer does not inhibit PLA 2 leading to both pro-inflammatory and pro-tumoral signaling pathways. Moreover, Annexin A1 promotes the release of cancer-derived exosomes, which also lead to the enrichment of PLA 2 and COX-1 and COX-2 enzymes, contributing to TME formation. In this review, we aim to describe the role of PLA 2 in the establishment of TME, focusing on cancer-derived exosomes, and modulatory activities of Annexin A1. Unraveling how these proteins interact in the cancer context can reveal new strategies for the treatment of different tumors. We will also describe the possible strategies to inhibit PLA 2 and the approaches that could be used in order to resume the anti-PLA 2 function of Annexin A1.
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فهرسة مساهمة: Keywords: Annexin A1; cancer aggressiveness; lipid metabolism; phospholipase A2; tumor microenvironment; tumorigenesis
المشرفين على المادة: 0 (Annexin A1)
EC 3.1.1.4 (Phospholipases A2)
تواريخ الأحداث: Date Created: 20210702 Date Completed: 20211108 Latest Revision: 20211108
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8231270
DOI: 10.3390/cells10061472
PMID: 34208346
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells10061472