دورية أكاديمية
أعرض في EDS

Chemoradiotherapy or chemotherapy as adjuvant treatment for resected gastric cancer: should we use selection criteria?

التفاصيل البيبلوغرافية
العنوان: Chemoradiotherapy or chemotherapy as adjuvant treatment for resected gastric cancer: should we use selection criteria?
المؤلفون: Mansouri H; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia., Zemni I; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.; Laboratory of Microorganisms and Active Biomolecules, Faculty of sciences, University of Tunis El Manar, Tunisia., Achouri L; Department of surgical oncology, Regional Hospital of Jendouba, Tunisia., Mahjoub N; Department of medical oncology, Regional Hospital of Jendouba, Tunisia., Ayedi MA; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.; Laboratory of Microorganisms and Active Biomolecules, Faculty of sciences, University of Tunis El Manar, Tunisia., Ben Safta I; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.; Laboratory of Microorganisms and Active Biomolecules, Faculty of sciences, University of Tunis El Manar, Tunisia., Ben Dhiab T; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia., Chargui R; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia., Rahal K; Department of Surgical Oncology, Salah Azaiez institute of oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
المصدر: Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology [Rep Pract Oncol Radiother] 2021 Apr 14; Vol. 26 (2), pp. 266-280. Date of Electronic Publication: 2021 Apr 14 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Via Medica Country of Publication: Poland NLM ID: 100885761 Publication Model: eCollection Cited Medium: Print ISSN: 1507-1367 (Print) Linking ISSN: 15071367 NLM ISO Abbreviation: Rep Pract Oncol Radiother Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2021- : Gdańsk, Poland : Via Medica
Original Publication: Poznań : Greatpoland Cancer Center and Polish Society of Radiation Oncology, 1998-
مستخلص: Background: The management of gastric adenocarcinoma is essentially based on surgery followed by adjuvant treatment. Adjuvant chemotherapy (CT) as well as chemoradiotherapy (CTRT) have proven their effectiveness in survival outcomes compared to surgery alone. However, there is little data comparing the two adjuvant approaches. This study aimed to compare the prognosis and survival outcomes of patients with gastric adenocarcinoma operated and treated by adjuvant radio-chemotherapy or chemotherapy.
Materials and Methods: We retrospectively evaluated 80 patients with locally advanced gastric cancer (LGC) who received adjuvant treatment. We compared survival outcomes and patterns of recurrence of 53 patients treated by CTRT and those of 27 patients treated by CT.
Results: After a median follow-up of 38.48 months, CTRT resulted in a significant improvement of the 5-year PFS (60.9% vs. 36%, p = 0.03) and the 5-year OS (55.9% vs. 33%, p = 0.015) compared to adjuvant CT. The 5-year OS was significantly increased by adjuvant CTRT (p = 0.046) in patients with lymph node metastasis, and particularly those with advanced pN stage (p = 0.0078) and high lymph node ratio (LNR) exceeding 25% (p = 0.012). Also, there was a significant improvement of the PFS of patients classified pN2-N3 (p = 0.022) with a high LNR (p = 0.018). CTRT was also associated with improved OS and PFS in patients with lymphovascular and perineural invasion (LVI and PNI) compared to chemotherapy.
Conclusion: There is a particular survival benefit of adding radiotherapy to chemotherapy in patients with selected criteria such as lymph node involvement, high LNR LVI, and PNI.
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
(© 2021 Greater Poland Cancer Centre.)
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فهرسة مساهمة: Keywords: chemoradiotherapy; chemotherapy; gastric cancer; survival
تواريخ الأحداث: Date Created: 20210702 Latest Revision: 20220424
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8241305
DOI: 10.5603/RPOR.a2021.0040
PMID: 34211778
قاعدة البيانات: MEDLINE
الوصف
تدمد:1507-1367
DOI:10.5603/RPOR.a2021.0040