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Atypical oral viral coinfection after allogeneic hematopoietic stem cell transplantation: Diagnosis and treatment challenge.

التفاصيل البيبلوغرافية
العنوان: Atypical oral viral coinfection after allogeneic hematopoietic stem cell transplantation: Diagnosis and treatment challenge.
المؤلفون: Schepanski N; Stomatology Department, Universidade Federal do Paraná, Curitiba, Brazil., Machado EFM; Stomatology Department, Universidade Federal do Paraná, Curitiba, Brazil., Sola CB; Department of Hematology and Oncology, Hospital de Clínicas Universidade Federal do Paraná, Curitiba, Brazil., Percicote AP; Medical Pathology Department, Universidade Federal do Paraná, Curitiba, Brazil., de Araujo MR; Stomatology Department, Universidade Federal do Paraná, Curitiba, Brazil.
المصدر: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [Spec Care Dentist] 2021 Nov; Vol. 41 (6), pp. 750-755. Date of Electronic Publication: 2021 Jul 03.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: American Dental Association Country of Publication: United States NLM ID: 8103755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-4505 (Electronic) Linking ISSN: 02751879 NLM ISO Abbreviation: Spec Care Dentist
أسماء مطبوعة: Original Publication: [Chicago : American Dental Association, c1981-
مواضيع طبية MeSH: Coinfection*/diagnosis , Coinfection*/drug therapy , Cytomegalovirus Infections* , Epstein-Barr Virus Infections*/diagnosis , Hematopoietic Stem Cell Transplantation*/adverse effects, Adult ; Herpesvirus 4, Human ; Humans ; Male
مستخلص: Background: Viral reactivation in patients undergoing immunosuppressive therapy after hematopoietic stem cell transplantation (HSCT) is a serious complication associated with significant morbidity and mortality. Infections caused by human herpes viruses such as herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) can result in oral lesions.
Case Presentation: A 40-year-old male patient who had undergone HSCT presented with ulcerated lesions in different areas of the mouth, for 7 months. The lesions had evolved to painful exophytic nodules with an erythematous, ulcerated surface. They were present on the tongue margins and soft and hard palate. Histological, immunohistochemical (IHC), and polymerase chain reaction analyses were performed, and the results were compatible with HSV-1 and -2 and CMV infections. Treatment comprised five sessions of antimicrobial photodynamic therapy (aPDT) and oral valganciclovir. Thirty days after combined antiviral therapy and aPDT, the lesions were completely resolved. Patient was followed up for 12 months without recurrence.
Conclusion: Diagnosis and treatment of atypical oral infections in immunosuppressed patients is challenging. Assessment of both clinical and laboratory findings is mandatory for a conclusive diagnosis. The use of local antimicrobial and systemic therapies contributes to positive clinical response in such cases.
(© 2021 Special Care Dentistry Association and Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: antiviral agents; cytomegalovirus; hematopoietic stem cell transplantation; herpes simplex virus; photodynamic therapy
تواريخ الأحداث: Date Created: 20210703 Date Completed: 20211112 Latest Revision: 20211112
رمز التحديث: 20240628
DOI: 10.1111/scd.12624
PMID: 34216159
قاعدة البيانات: MEDLINE
الوصف
تدمد:1754-4505
DOI:10.1111/scd.12624