دورية أكاديمية
أعرض في EDS

Health-related quality of life of early-stage breast cancer patients after different radiotherapy regimens.

التفاصيل البيبلوغرافية
العنوان: Health-related quality of life of early-stage breast cancer patients after different radiotherapy regimens.
المؤلفون: Jacobs DHM; Department of Radiation Oncology, Leiden University Medical Center, Albinusdreef 2, PO box 9600, 2300 RC, Leiden, The Netherlands. d.h.m.jacobs@lumc.nl.; Department of Radiation Oncology, Haaglanden Medical Center, Burgemeester Banninglaan, 2262 BA, Leidschendam, The Netherlands. d.h.m.jacobs@lumc.nl., Charaghvandi RK; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands., Horeweg N; Department of Radiation Oncology, Leiden University Medical Center, Albinusdreef 2, PO box 9600, 2300 RC, Leiden, The Netherlands., Maduro JH; Department of Radiation Oncology, University Medical Center, Groningen, Groningen, The Netherlands., Speijer G; Department of Radiation Oncology, Haga Hospital, The Hague, The Netherlands., Roeloffzen EMA; Department of Radiation Oncology, Isala Clinics, Zwolle, The Netherlands., Mast M; Department of Radiation Oncology, Haaglanden Medical Center, Burgemeester Banninglaan, 2262 BA, Leidschendam, The Netherlands., Bantema-Joppe E; Department of Radiation Oncology, Radiotherapy Institute Friesland, Friesland, The Netherlands., Petoukhova AL; Department of Radiation Oncology, Haaglanden Medical Center, Burgemeester Banninglaan, 2262 BA, Leidschendam, The Netherlands., van den Bongard DHJG; Department of Radiation Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Koper P; Department of Radiation Oncology, Haaglanden Medical Center, Burgemeester Banninglaan, 2262 BA, Leidschendam, The Netherlands., Crijns APG; Department of Radiation Oncology, University Medical Center, Groningen, Groningen, The Netherlands., Marijnen CAM; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Verkooijen HM; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Sep; Vol. 189 (2), pp. 387-398. Date of Electronic Publication: 2021 Jul 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer Academic
Original Publication: The Hague ; Boston : M. Nijhoff, c1981-
مواضيع طبية MeSH: Breast Neoplasms*/radiotherapy , Breast Neoplasms*/surgery, Breast ; Child, Preschool ; Female ; Humans ; Infant ; Mastectomy, Segmental ; Prospective Studies ; Quality of Life
مستخلص: Purpose: To evaluate and compare health-related quality of life (HRQL) of women with early-stage breast cancer (BC) treated with different radiotherapy (RT) regimens.
Methods: Data were collected from five prospective cohorts of BC patients treated with breast-conserving surgery and different RT regimens: intraoperative RT (IORT, 1 × 23.3 Gy; n = 267), external beam accelerated partial breast irradiation (EB-APBI, 10 × 3.85 Gy; n = 206), hypofractionated whole breast irradiation(hypo-WBI, 16 × 2.67 Gy; n = 375), hypo-WBI + boost(hypo-WBI-B, 21-26 × 2.67 Gy; n = 189), and simultaneous WBI + boost(WBI-B, 28 × 2.3 Gy; n = 475). Women ≥ 60 years with invasive/in situ carcinoma ≤ 30 mm, cN0 and pN0-1a were included. Validated EORTC QLQ-C30/BR23 questionnaires were used to asses HRQL. Multivariable linear regression models adjusted for confounding (age, comorbidity, pT, locoregional treatment, systemic therapy) were used to compare the impact of the RT regimens on HRQL at 12 and 24 months. Differences in HRQL over time (3-24 months) were evaluated using linear mixed models.
Results: There were no significant differences in HRQL at 12 months between groups except for breast symptoms which were better after IORT and EB-APBI compared to hypo-WBI at 12 months (p < 0.001). Over time, breast symptoms, fatigue, global health status and role functioning were significantly better after IORT and EB-APBI than hypo-WBI. At 24 months, HRQL was comparable in all groups.
Conclusion: In women with early-stage breast cancer, the radiotherapy regimen did not substantially influence long-term HRQL with the exception of breast symptoms. Breast symptoms are more common after WBI than after IORT or EB-APBI and improve slowly until no significant difference remains at 2 years posttreatment.
(© 2021. The Author(s).)
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فهرسة مساهمة: Keywords: Accelerated Partial Breast Irradiation; Early-stage breast cancer; Health-related quality of life; Intraoperative radiotherapy
تواريخ الأحداث: Date Created: 20210703 Date Completed: 20210813 Latest Revision: 20211109
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8357747
DOI: 10.1007/s10549-021-06314-4
PMID: 34216316
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7217
DOI:10.1007/s10549-021-06314-4