دورية أكاديمية
أعرض في EDS

Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines.

التفاصيل البيبلوغرافية
العنوان: Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines.
المؤلفون: Wang W; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Sindrewicz-Goral P; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Chen C; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Duckworth CA; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Pritchard DM; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Rhodes JM; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK., Yu LG; The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK.
المصدر: Carcinogenesis [Carcinogenesis] 2021 Aug 19; Vol. 42 (8), pp. 1079-1088.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Irl Press At Oxford University Press
Original Publication: [New York, IRL Press]
مواضيع طبية MeSH: Arachis*, Cytokines/*metabolism , Neoplasm Metastasis/*pathology , Peanut Agglutinin/*blood, Animals ; Cell Adhesion Molecules/metabolism ; Cells, Cultured ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Female ; Humans ; Inflammation Mediators/metabolism ; Mice ; Mice, Inbred BALB C ; Mucin-1/metabolism ; Peanut Agglutinin/pharmacology ; Signal Transduction
مستخلص: Peanut agglutinin (PNA) is a carbohydrate-binding protein in peanuts that accounts for ~0.15% peanut weight. PNA is highly resistant to cooking and digestion and is rapidly detectable in the blood after peanut consumption. Our previous studies have shown that circulating PNA mimics the actions of endogenous galactoside-binding protein galectin-3 by interaction with tumour cell-associated MUC1 and promotes circulating tumour cell metastatic spreading. The present study shows that circulating PNA interacts with micro- as well as macro-vascular endothelial cells and induces endothelial secretion of cytokines MCP-1 (CCL2) and IL-6 in vitro and in vivo. The increased secretion of these cytokines autocrinely/paracrinely enhances the expression of endothelial cell surface adhesion molecules including integrins, VCAM and selectin, leading to increased tumour cell-endothelial adhesion and endothelial tubule formation. Binding of PNA to endothelial surface MCAM (CD146), via N-linked glycans, and subsequent activation of PI3K-AKT-PREAS40 signalling is here shown responsible for PNA-induced secretion of MCP-1 and IL-6 by vascular endothelium. Thus, in addition to its influence on promoting tumour cell spreading by interaction with tumour cell-associated MUC1, circulating PNA might also influence metastasis by enhancing the secretion of metastasis-promoting MCP-1 and IL-6 from the vascular endothelium.
(© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
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معلومات مُعتمدة: 10A001 American Institute for Cancer Research
المشرفين على المادة: 0 (Cell Adhesion Molecules)
0 (Cytokines)
0 (Inflammation Mediators)
0 (MUC1 protein, human)
0 (Mucin-1)
0 (Peanut Agglutinin)
تواريخ الأحداث: Date Created: 20210705 Date Completed: 20211220 Latest Revision: 20211220
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8643467
DOI: 10.1093/carcin/bgab059
PMID: 34223877
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2180
DOI:10.1093/carcin/bgab059