دورية أكاديمية
A pediatric BAL case with double Ph chromosomes and trisomy 5.
| العنوان: | A pediatric BAL case with double Ph chromosomes and trisomy 5. |
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| المؤلفون: | Gunden G; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey. Electronic address: gulcin.gunden@ogu.edu.tr., Isik S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey. Electronic address: sisik@ogu.edu.tr., Ozdemir C; Department of Pediatric Hematology, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Cİlİngİr O; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Bor O; Department of Pediatric Hematology, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Gokalp EE; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Kocagil S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Artan S; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey., Aras BD; Department of Medical Genetics, Faculty of Medicine, University of Eskisehir Osmangazi, Eskisehir, Turkey. |
| المصدر: | Cancer genetics [Cancer Genet] 2021 Nov; Vol. 258-259, pp. 7-9. Date of Electronic Publication: 2021 Jun 22. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101539150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-7762 (Print) NLM ISO Abbreviation: Cancer Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier |
| مواضيع طبية MeSH: | Chromosome Aberrations* , Gene Rearrangement* , Philadelphia Chromosome*, Cri-du-Chat Syndrome/*genetics , Leukemia, Biphenotypic, Acute/*genetics , Leukemia, Biphenotypic, Acute/*pathology , Trisomy/*genetics, Child, Preschool ; Chromosomes, Human, Pair 5/genetics ; Humans ; Male ; Prognosis |
| مستخلص: | Biphenotypic acute leukemias (BAL) are known as a type of leukemia involving cells with myeloid and along with lymphoid origin, in which genomic changes are detected. It has been stated that the most common genomic changes in BAL are t(9;22) and the translocations of the 11q23 region, these anomalies cause poor prognostic effects. We detected trisomy 5 (+5) in addition to the double Ph chromosome in a case where we investigated the genomic changes using molecular and conventional cytogenetic methods. Bone marrow transplantation was planned due to the poor response to prednisone. According to the information we have obtained, our report will be the first article to discuss the aberrations found in addition to the Ph chromosome in BAL and the effect of these aberrations on prognosis. However, the double observation of the Ph chromosome, which has a poor prognostic effect, is expected to affect the prognosis more negatively, this case will contribute to the literature in terms of trisomy 5. We think that more case reports are needed to reveal the anomalies and their prognostic significance in BAL. Competing Interests: Declaration of Competing Interest None (Copyright © 2021. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: BAL; Cytogenetics; FISH; Trisomy 5 |
| SCR Disease Name: | Chromosome 5, trisomy 5q |
| تواريخ الأحداث: | Date Created: 20210705 Date Completed: 20211224 Latest Revision: 20211224 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cancergen.2021.06.005 |
| PMID: | 34225100 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2210-7762 |
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| DOI: | 10.1016/j.cancergen.2021.06.005 |