دورية أكاديمية
أعرض في EDS

Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness.

التفاصيل البيبلوغرافية
العنوان: Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness.
المؤلفون: Mortier J; KU Leuven, Department of Microbial and Molecular Systems, Leuven, Belgium., Gayán E; KU Leuven, Department of Microbial and Molecular Systems, Leuven, Belgium., Van Eyken R; KU Leuven, Department of Microbial and Molecular Systems, Leuven, Belgium., Torres Montaguth OE; KU Leuven, Department of Microbial and Molecular Systems, Leuven, Belgium., Khodaparast L; KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium., Khodaparast L; KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium., Houben B; KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium., Carpentier S; KU Leuven, SYBIOMA: Facility for Systems Biology Mass Spectrometry, Leuven, Belgium., Rousseau F; KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium., Schymkowitz J; KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium., Aertsen A; KU Leuven, Department of Microbial and Molecular Systems, Leuven, Belgium.
المصدر: MBio [mBio] 2021 Aug 31; Vol. 12 (4), pp. e0112921. Date of Electronic Publication: 2021 Jul 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Society for Microbiology
مواضيع طبية MeSH: Alleles* , Gain of Function Mutation* , Genetic Fitness*, Escherichia coli/*genetics, Directed Molecular Evolution/methods ; Escherichia coli/metabolism ; Gene Expression Regulation, Bacterial ; Heat-Shock Proteins/metabolism ; Heat-Shock Response/genetics ; Mutation
مستخلص: Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In this report, directed evolution experiments using the Escherichia coli model system unexpectedly revealed that seemingly random single mutations in its tnaA gene can confer significant heat resistance. Closer examination, however, indicated that these mutations create folding-deficient and aggregation-prone TnaA variants that in turn can endogenously and preemptively trigger HSP expression to cause heat resistance. These findings, importantly, demonstrate that even erosive mutations with disruptive effects on protein structure and functionality can still yield true gain-of-function alleles with a selective advantage in adaptive evolution.
التعليقات: Erratum in: mBio. 2021 Oct 26;12(5):e0246721. (PMID: 34579575)
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فهرسة مساهمة: Keywords: evolution; genetics; heat resistance; protein aggregates
المشرفين على المادة: 0 (Heat-Shock Proteins)
تواريخ الأحداث: Date Created: 20210706 Date Completed: 20211231 Latest Revision: 20211231
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8406189
DOI: 10.1128/mBio.01129-21
PMID: 34225482
قاعدة البيانات: MEDLINE
الوصف
تدمد:2150-7511
DOI:10.1128/mBio.01129-21