دورية أكاديمية
Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions.
| العنوان: | Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions. |
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| المؤلفون: | Hulsman AM; Experimental Psychopathology & Treatment, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands; Affective Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Terburg D; Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Roelofs K; Experimental Psychopathology & Treatment, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands; Affective Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands., Klumpers F; Experimental Psychopathology & Treatment, Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands; Affective Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands. Electronic address: f.klumpers@donders.ru.nl. |
| المصدر: | Handbook of clinical neurology [Handb Clin Neurol] 2021; Vol. 179, pp. 419-432. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0166161 Publication Model: Print Cited Medium: Internet ISSN: 0072-9752 (Print) Linking ISSN: 00729752 NLM ISO Abbreviation: Handb Clin Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1985- >: Amsterdam ; New York : Elsevier Original Publication: Amsterdam [Netherlands] : New York : North-Holland Pub. Co. ; Wiley Interscience Division - John Wiley & Sons, [©1969- |
| مواضيع طبية MeSH: | Septal Nuclei*, Amygdala ; Fear ; Humans ; Learning ; Magnetic Resonance Imaging |
| مستخلص: | The bed nucleus of the stria terminalis (BNST) plays a critical modulatory role in driving fear responses. Part of the so-called extended amygdala, this region shares many functions and connections with the substantially more investigated amygdala proper. In this chapter, we review contributions of the BNST and amygdala to subjective, behavioral, and physiological aspects of fear. Despite the fact that both regions are together involved in each of these aspects of fear, they appear complimentary in their contributions. Specifically, the basolateral amygdala (BLA), through its connections to sensory and orbitofrontal regions, is ideally poised for fast learning and controlling fear reactions in a variety of situations. The central amygdala (CeA) relies on BLA input and is particularly important for adjusting physiological and behavioral responses under acute threat. In contrast, the BNST may profit from more extensive striatal and dorsomedial prefrontal connections to drive anticipatory responses under more ambiguous conditions that allow more time for planning. Thus current evidence suggests that the BNST is ideally suited to play a critical role responding to distant or ambiguous threats and could thereby facilitate goal-directed defensive action. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amygdala; Anxiety; Avoidance; Bed nucleus of the stria terminalis; Deep brain stimulation; Fear; Lesion studies; Threat anticipation; Threat imminence; fMRI |
| تواريخ الأحداث: | Date Created: 20210706 Date Completed: 20210728 Latest Revision: 20210728 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/B978-0-12-819975-6.00027-3 |
| PMID: | 34225979 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0072-9752 |
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| DOI: | 10.1016/B978-0-12-819975-6.00027-3 |