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Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults.

التفاصيل البيبلوغرافية
العنوان: Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults.
المؤلفون: Zahed H; Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France., Johansson M; Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France., Ueland PM; Department of Clinical Science, University of Bergen, Bergen, Norway., Midttun Ø; Bevital AS, Bergen, Norway., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia., Manjer J; Department of Surgery, Skane University Hospital, Malmö, Sweden.; Lund University, Malmö, Sweden., Sandsveden M; Department of Clinical Sciences Malmo, Lund University, Malmö, Sweden., Langhammer A; Department of Public Health and Nursing, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Sørgjerd EP; Department of Public Health and Nursing, NTNU, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Levanger, Norway., Grankvist K; Department of Medical Biosciences, Umea University, Umeå, Sweden., Johansson M; Department of Radiation Sciences, Oncology, Umea University, Umeå, Sweden., Freedman ND; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Huang WY; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Chen C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA., Prentice R; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA., Stevens VL; American Cancer Society, Atlanta, USA., Wang Y; American Cancer Society, Atlanta, USA., Le Marchand L; University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, USA., Wilkens LR; University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, USA., Weinstein SJ; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Albanes D; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Cai Q; Vanderbilt University Medical Center, Nashville, USA., Blot WJ; Vanderbilt University Medical Center, Nashville, USA., Arslan AA; Department of Obstetrics and Gynecology, NYU Langone Health, New York, NY, USA.; Department of Population Health, NYU Langone Health, New York, NY, USA.; Perlmutter Comprehensive Cancer Center, NYU Langone Health, New York, NY, USA., Zeleniuch-Jacquotte A; Department of Population Health, NYU Langone Health, New York, NY, USA.; Perlmutter Comprehensive Cancer Center, NYU Langone Health, New York, NY, USA., Shu XO; Vanderbilt University Medical Center, Nashville, USA., Zheng W; Vanderbilt University Medical Center, Nashville, USA., Yuan JM; University of Pittsburgh Medical Center, Pittsburgh, USA., Koh WP; Duke - NUS Medical School, Singapore, Singapore., Visvanathan K; Johns Hopkins Institute for Clinical and Translational Research, Baltimore, USA., Sesso HD; Brigham and Women's Hospital, Harvard Medical School, Boston, USA.; Harvard T.H. Chan School of Public Health, Boston, USA., Zhang X; Brigham and Women's Hospital, Harvard Medical School, Boston, USA.; Harvard T.H. Chan School of Public Health, Boston, USA., Gaziano JM; Harvard T.H. Chan School of Public Health, Boston, USA.; Brigham and Women's Hospital, Boston, USA., Fanidi A; Université Claude Bernard Lyon 1, Lyon, France., Muller D; Imperial College London School of Public Health, London, UK., Brennan P; Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France., Guida F; Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France., Robbins HA; Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008, Lyon, France. RobbinsH@iarc.fr.
المصدر: Scientific reports [Sci Rep] 2021 Jul 05; Vol. 11 (1), pp. 13805. Date of Electronic Publication: 2021 Jul 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Biomarkers/*blood , Carbon/*metabolism , Inflammation/*genetics , Kidney/*metabolism, Aged ; Aged, 80 and over ; Body Mass Index ; C-Reactive Protein/genetics ; Female ; Humans ; Inflammation/blood ; Inflammation/metabolism ; Inflammation/pathology ; Kynurenine/blood ; Male ; Middle Aged ; Smoking/genetics ; Smoking Cessation ; Vitamins/blood
مستخلص: Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40-80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was - 0.91 standard-deviations lower in women than men (95%CI - 0.98; - 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m 2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation.
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معلومات مُعتمدة: HHSN268201600001C United States HL NHLBI NIH HHS; HHSN268201600003C United States HL NHLBI NIH HHS; UM1 CA173640 United States CA NCI NIH HHS; P30 ES000260 United States ES NIEHS NIH HHS; UM1 CA182876 United States CA NCI NIH HHS; U19 CA203654 United States CA NCI NIH HHS; P30 CA016087 United States CA NCI NIH HHS; U01 CA182934 United States CA NCI NIH HHS; HHSN268201600002C United States HL NHLBI NIH HHS; U01 CA164973 United States CA NCI NIH HHS; HHSN268201600004C United States HL NHLBI NIH HHS; HHSN268201600018C United States HL NHLBI NIH HHS; U01 CA167552 United States CA NCI NIH HHS; UM1 CA186107 United States CA NCI NIH HHS; 001 International WHO_ World Health Organization; P50 CA127003 United States CA NCI NIH HHS; R01 CA144034 United States CA NCI NIH HHS; U01 CA155340 United States CA NCI NIH HHS; UM1 CA182910 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (Vitamins)
343-65-7 (Kynurenine)
7440-44-0 (Carbon)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20210706 Date Completed: 20211105 Latest Revision: 20240324
رمز التحديث: 20240324
مُعرف محوري في PubMed: PMC8257595
DOI: 10.1038/s41598-021-93214-8
PMID: 34226613
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-93214-8