دورية أكاديمية
أعرض في EDS

Hyperion Image Analysis Depicts a Preliminary Landscape of Tumor Immune Microenvironment in OSCC with Lymph Node Metastasis.

التفاصيل البيبلوغرافية
العنوان: Hyperion Image Analysis Depicts a Preliminary Landscape of Tumor Immune Microenvironment in OSCC with Lymph Node Metastasis.
المؤلفون: Xie S; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China., Zhang XY; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China., Shan XF; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China., Yau V; Stony Brook University School of Dental Medicine, South Drive, Stony Brook, NY 11794, USA., Zhang JY; Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China., Wang W; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China., Yan YP; Gencode Diagnostics Inc., #7 Liye Road, 5th Floor, Changping District, Beijing 102206, China., Cai ZG; Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
المصدر: Journal of immunology research [J Immunol Res] 2021 Jun 21; Vol. 2021, pp. 9975423. Date of Electronic Publication: 2021 Jun 21 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156 (Electronic) Linking ISSN: 23147156 NLM ISO Abbreviation: J Immunol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cairo, Egypt : Hindawi Publishing Corporation, [2014]-
مواضيع طبية MeSH: Laser Scanning Cytometry/*instrumentation , Lymphatic Metastasis/*immunology , Mouth Mucosa/*diagnostic imaging , Mouth Neoplasms/*immunology , Squamous Cell Carcinoma of Head and Neck/*immunology , Tumor Microenvironment/*immunology, Adult ; Female ; Humans ; Image Processing, Computer-Assisted ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Male ; Mouth Mucosa/immunology ; Mouth Mucosa/pathology ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Mouth Neoplasms/surgery ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/diagnosis ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/surgery
مستخلص: Background: Oral squamous cell carcinoma (OSCC) constitutes the most common types of oral cancer. Because its prognosis varies significantly, identification of a tumor immune microenvironment could be a critical tool for treatment planning and predicting a more accurate prognosis. This study is aimed at utilizing the Hyperion imaging system to depict a preliminary landscape of the tumor immune microenvironment in OSCC with lymph node metastasis.
Methods: We collected neoplasm samples from OSCC patients. Their formalin-fixed, paraffin-embedded (FFPE) tissue sections were obtained and stained utilizing a panel of 26 clinically relevant metal-conjugated antibodies. Detection and analysis were performed for these stained cells with the Hyperion imaging system.
Results: Four patients met our inclusion criteria. We depicted a preliminary landscape of their tumor immune microenvironment and identified 25 distinct immune cell subsets from these OSCC patients based on phenotypic similarity. All these patients had decreased expression of CD8 + T cells in tumor specimens. Variety in cell subsets was seen, and more immune activated cells were found in patient A and patient B than those in patient C and patient D. Such differences in tumor immune microenvironments can contribute to forecasting of individual prognoses.
Conclusion: The Hyperion imaging system helped to delineate a preliminary and multidimensional landscape of the tumor immune microenvironment in OSCC with lymph node metastasis and provided insights into the influence of the immune microenvironment in determination of prognoses. These results reveal possible contributory factors behind different prognoses of OSCC patients with lymph node metastasis and provide reference for individual treatment planning.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Shang Xie et al.)
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تواريخ الأحداث: Date Created: 20210709 Date Completed: 20211215 Latest Revision: 20220424
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8238606
DOI: 10.1155/2021/9975423
PMID: 34239944
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-7156
DOI:10.1155/2021/9975423