SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data.

التفاصيل البيبلوغرافية
العنوان:	SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data.
المؤلفون:	Nguyen D; University of Oxford, Oxford, United Kingdom., Simmonds P; University of Oxford, Oxford, United Kingdom., Steenhuis M; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Amsterdam, Netherlands., Wouters E; Transfusion Research Centre, Belgian Red Cross-Flanders, Ghent, Belgium., Desmecht D; Department of Pathology, Faculty of Veterinary Medicine, Liège University, Liège, Belgium., Garigliany M; Department of Pathology, Faculty of Veterinary Medicine, Liège University, Liège, Belgium., Romano M; Immune Response service, Sciensano, Brussels, Belgium., Barbezange C; National Influenza Centre, Sciensano, Brussels, Belgium., Maes P; KU Leuven, Rega Institute, Clinical and Epidemiological Virology, Leuven, Belgium., Van Holm B; KU Leuven, Rega Institute, Clinical and Epidemiological Virology, Leuven, Belgium., Mendoza J; Vircell SL, Granada, Spain., Oyonarte S; Andalusian Network of Transfusion Medicine, Tissues and Cells, Sevilla, Spain., Fomsgaard A; Virus and Microbiological Special Diagnostics, Statens Serum Institute, Copenhagen, Denmark., Lassaunière R; Virus and Microbiological Special Diagnostics, Statens Serum Institute, Copenhagen, Denmark., Zusinaite E; Tartu University Institute of Technology, Tartu, Estonia., Resman Rus K; Institute of Microbiology and Immunology, Ljubljana, Slovenia., Avšič-Županc T; Institute of Microbiology and Immunology, Ljubljana, Slovenia., Reimerink JH; Centre for Infectious Disease Control, WHO COVID-19 Reference Laboratory, RIVML, Bilthoven, the Netherlands., Brouwer F; Centre for Infectious Disease Control, WHO COVID-19 Reference Laboratory, RIVML, Bilthoven, the Netherlands., Hoogerwerf M; Centre for Infectious Disease Control, WHO COVID-19 Reference Laboratory, RIVML, Bilthoven, the Netherlands., Reusken CB; Centre for Infectious Disease Control, WHO COVID-19 Reference Laboratory, RIVML, Bilthoven, the Netherlands., Grodeland G; Dep. of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway., Le Cam S; Etablissement Français du Sang, La Plaine Saint Denis, France., Gallian P; Etablissement Français du Sang, La Plaine Saint Denis, France.; Unité des Virus Émergents (Aix-Marseille University - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France., Amroun A; Unité des Virus Émergents (Aix-Marseille University - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France., Brisbarre N; Unité des Virus Émergents (Aix-Marseille University - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.; Etablissement français du Sang Provence Alpes Côte d'Azur et Corse, Marseille, France., Martinaud C; Centre de Transfusion Sanguine des Armées, Clamart, France., Leparc Goffart I; Unité de Virologie, Institut de Recherche Biomédicale des Armées, Marseille, France., Schrezenmeier H; Department of Transfusion Medicine, Ulm University, Ulm, Germany.; Institute for Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service Baden-Wurttemberg - Hessen and University Hospital Ulm, Ulm, Germany., Feys HB; Transfusion Research Centre, Belgian Red Cross-Flanders, Ghent, Belgium., van der Schoot CE; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Amsterdam, Netherlands., Harvala H; Microbiology Services, NHS Blood and Transplant, Colindale, United Kingdom.; University College of London, London, United Kingdom.
المصدر:	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2021 Jul; Vol. 26 (27).
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: European Centre for Disease Prevention and Control (ECDC) Country of Publication: Sweden NLM ID: 100887452 Publication Model: Print Cited Medium: Internet ISSN: 1560-7917 (Electronic) Linking ISSN: 1025496X NLM ISO Abbreviation: Euro Surveill Subsets: MEDLINE
أسماء مطبوعة:	Publication: Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC) Original Publication: Saint-Maurice : Hôpital national de Saint-Maurice
مواضيع طبية MeSH:	COVID-19/therapy , SARS-CoV-2, Antibodies, Neutralizing ; Antibodies, Viral ; Europe ; Humans ; Immunization, Passive ; COVID-19 Serotherapy
مستخلص:	We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies.
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فهرسة مساهمة:	Keywords: Europe; SARS-CoV-2; convalescent plasma; neutralising antibodies; standardisation, COVID-19
المشرفين على المادة:	0 (Antibodies, Neutralizing) 0 (Antibodies, Viral)
تواريخ الأحداث:	Date Created: 20210709 Date Completed: 20210713 Latest Revision: 20221207
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC8268650
DOI:	10.2807/1560-7917.ES.2021.26.27.2100568
PMID:	34240697
قاعدة البيانات:	MEDLINE

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تدمد:	1560-7917
DOI:	10.2807/1560-7917.ES.2021.26.27.2100568