دورية أكاديمية
Computational studies and sever apoptotic bioactivity of new heterocyclic cyanoacrylamide based p-fluorophenyl and p-phenolic compounds against liver carcinoma (Hepg2).
| العنوان: | Computational studies and sever apoptotic bioactivity of new heterocyclic cyanoacrylamide based p-fluorophenyl and p-phenolic compounds against liver carcinoma (Hepg2). |
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| المؤلفون: | Mohamed MF; Department of Chemistry, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: magdafikry85@yahoo.com., Saddiq AA; Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Al-Shaikh TM; Department of Biology, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia., Ibrahim NS; Department of Chemistry (Biochemistry Branch), Faculty of Science, Cairo University, Giza 12613, Egypt., Abdelhamid IA; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: ismail_shafy@yahoo.com. |
| المصدر: | Bioorganic chemistry [Bioorg Chem] 2021 Sep; Vol. 114, pp. 105147. Date of Electronic Publication: 2021 Jul 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Acrylamide/*pharmacology , Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Carcinoma, Hepatocellular/*drug therapy , Heterocyclic Compounds/*pharmacology , Liver Neoplasms/*drug therapy , Phenols/*pharmacology, Acrylamide/chemistry ; Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Heterocyclic Compounds/chemistry ; Humans ; Liver Neoplasms/pathology ; Molecular Docking Simulation ; Molecular Structure ; Phenols/chemistry ; Structure-Activity Relationship |
| مستخلص: | An efficient route for the preparation of new heterocyclic cyanoacrylamides based p-fluorophenyl and p-phenolic compounds was depicted. All structures were confirmed based on the different spectral tools and elemental analyses. MTT assay for the novel synthesized series was performed against four different cell lines (A549, MCF7, Hepg2, and Wi38). Among all tested groups, the p-phenolic compound 10 (207.1 µg/ml) and the corresponding p-fluorophenyl derivative 6 (325.7 µg/ml) were selected for further simulation and molecular studies against liver carcinoma. Compounds 6 and 10 were investigated theoretically to different protein sets as (cdk2, Bcl2-xl, cIAP1-BIR3, and MDM2) and they illustrated different binding affinities. The computational studies and different molecular techniques (e.g. cell cycle analysis, DPA assay, relative gene expression, and ELISA assay) were utilized in this report. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 2-Cyanoacrylamide based p-fluorophenyl and p-phenolic compounds; Apoptosis; Caspases 3,8,9; Cell cycle; P53; RT- PCR |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Heterocyclic Compounds) 0 (Phenols) 20R035KLCI (Acrylamide) |
| تواريخ الأحداث: | Date Created: 20210710 Date Completed: 20211209 Latest Revision: 20211214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bioorg.2021.105147 |
| PMID: | 34246114 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2021.105147 |