دورية أكاديمية
أعرض في EDS

Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.

التفاصيل البيبلوغرافية
العنوان: Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.
المؤلفون: Mongiovi JM; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.; Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, United States., Hong CC; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Zirpoli GR; Slone Epidemiology Center, Boston University, Boston, NY, United States., Khoury T; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Omilian AR; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Qin B; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States., Bandera EV; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, United States., Yao S; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Ambrosone CB; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States., Gong Z; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
المصدر: Frontiers in oncology [Front Oncol] 2021 Jun 24; Vol. 11, pp. 679998. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX -related pathways and examined their associations with breast cancer risk among 1,275 White and 1,299 Black cases and controls who participated in the Women's Circle of Health Study. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable-adjusted logistic regression models. Our results showed differential associations of certain genetic variants with breast cancer according to menopausal and ER status in either White or Black women. In White women, an increased risk of breast cancer was observed for COX2 -rs689470 (OR: 2.02, P = 0.01) in the dominant model, and was strongest among postmenopausal women (OR: 2.72, P = 0.02) and for estrogen receptor positive (ER+) breast cancers (OR: 2.60, P = 0.001). A reduced risk was observed for ALOX5 -rs7099874 (OR: 0.75, P = 0.01) in the dominant model, and was stronger among postmenopausal women (OR: 0.68, P = 0.03) and for ER+ cancer (OR: 0.66, P = 0.001). Four SNPs (rs3840880, rs1126667, rs434473, rs1042357) in the ALOX12 gene were found in high LD (r 2 >0.98) in White women and were similarly associated with reduced risk of breast cancer, with a stronger association among postmenopausal women and for ER- cancer. Among Black women, increased risk was observed for ALOX5 -rs1369214 (OR: 1.44, P = 0.003) in the recessive model and was stronger among premenopausal women (OR: 1.57, P = 0.03) and for ER+ cancer (OR: 1.53, P = 0.003). Our study suggests that genetic variants of COX2 and ALOX genes are associated with breast cancer, and that these associations and genotype distributions differ in subgroups defined by menopausal and ER status between White and Black women. Findings may provide insights into the etiology of breast cancer and areas for further research into reasons for breast cancer differences between races.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Mongiovi, Hong, Zirpoli, Khoury, Omilian, Qin, Bandera, Yao, Ambrosone and Gong.)
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فهرسة مساهمة: Keywords: 5-LOX; Black women; arachidonate 12-lipoxygenase; breast cancer; cyclooxygenase 2; polymorphism
تواريخ الأحداث: Date Created: 20210712 Latest Revision: 20210713
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8263909
DOI: 10.3389/fonc.2021.679998
PMID: 34249719
قاعدة البيانات: MEDLINE
الوصف
تدمد:2234-943X
DOI:10.3389/fonc.2021.679998