Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study.

التفاصيل البيبلوغرافية
العنوان:	Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study.
المؤلفون:	Zelepukin IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.; Moscow Institute of Physics and Technology, Moscow 141701, Russia.; National Research Nuclear University 'MEPhI', Moscow 115409, Russia., Yaremenko AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.; Moscow Institute of Physics and Technology, Moscow 141701, Russia., Ivanov IN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.; National Research Nuclear University 'MEPhI', Moscow 115409, Russia.; Pirogov Russian National Research Medical University (RNRMU), Moscow 117997, Russia., Yuryev MV; Moscow Institute of Physics and Technology, Moscow 141701, Russia.; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia., Cherkasov VR; Moscow Institute of Physics and Technology, Moscow 141701, Russia.; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia., Deyev SM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.; National Research Nuclear University 'MEPhI', Moscow 115409, Russia., Nikitin PI; National Research Nuclear University 'MEPhI', Moscow 115409, Russia.; Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia., Nikitin MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow 117997, Russia.; Moscow Institute of Physics and Technology, Moscow 141701, Russia.; Sirius University of Science and Technology, Sochi 354340, Russia.
المصدر:	ACS nano [ACS Nano] 2021 Jul 27; Vol. 15 (7), pp. 11341-11357. Date of Electronic Publication: 2021 Jul 12.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Washington D.C. : American Chemical Society
مواضيع طبية MeSH:	Polyethylene Glycols* , Nanoparticles*, Mice ; Animals ; Polymers ; Physical Phenomena ; Magnetic Phenomena ; Particle Size
مستخلص:	Safe application of nanoparticles in medicine requires full understanding of their pharmacokinetics including catabolism in the organism. However, information about nanoparticle degradation is still scanty due to difficulty of long-term measurements by invasive techniques. Here, we describe a magnetic spectral approach for in vivo monitoring of magnetic particle (MP) degradation. The method noninvasiveness has allowed performing of a broad comprehensive study of the 1-year fate of 17 types of iron oxide particles. We show a long-lasting influence of five parameters on the MP degradation half-life: dose, hydrodynamic size, ζ-potential, surface coating, and internal architecture. We observed a slowdown in MP biotransformation with an increase of the injected dose and faster degradation of the particles of a small hydrodynamic size. A comparison of six types of 100 nm particles coated by different hydrophilic polymer shells has shown that the slowest ( t 1/2 = 38 ± 6 days) and the fastest ( t 1/2 = 15 ± 4 days) degradations were achieved with a polyethylene glycol and polyglucuronic acid coatings, respectively. The most significant influence on the MP degradation was due to the internal architecture of the particles as the coverage of magnetic cores with a solid 39 nm polystyrene layer slowed down the half-life of the core-shell MPs from 48 days to more than 1 year. The revealed deeper insights into the particle degradation in vivo may facilitate rational design of nano- and microparticles with predictable long-term fate in vivo .
فهرسة مساهمة:	Keywords: biodegradation; biodistribution; iron oxide nanoparticles; magnetic particle detection; nanotoxicity; noninvasive detection
المشرفين على المادة:	3WJQ0SDW1A (Polyethylene Glycols) 0 (Polymers)
تواريخ الأحداث:	Date Created: 20210712 Date Completed: 20221110 Latest Revision: 20221222
رمز التحديث:	20221222
DOI:	10.1021/acsnano.1c00687
PMID:	34250790
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1936-086X
DOI:	10.1021/acsnano.1c00687