دورية أكاديمية
Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium falciparum Malaria in Bohicon and Kandi, Republic of Benin, 2018-2019.
| العنوان: | Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium falciparum Malaria in Bohicon and Kandi, Republic of Benin, 2018-2019. |
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| المؤلفون: | Kpemasse A; 1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin., Dagnon F; 2U.S. President's Malaria Initiative, U.S. Agency for International Development Benin Office, Cotonou, Benin., Saliou R; 1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin., Yarou Maye AS; 1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin., Affoukou CD; 1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin., Zoulkaneri A; 3Kandi Health Center, Alibori Department, Benin Ministry of Health, Kandi, Benin., Guézo-Mévo B; 4Bohicon Health Center, Zou Department, Benin Ministry of Health, Bohicon, Benin., Moriarty LF; 5Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, and the U.S. President's Malaria Initiative, Atlanta, Georgia., Ndiaye YD; 6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal., Garba MN; 6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal., Deme AB; 6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal., Ndiaye D; 6Molecular Biology and Genomics Laboratory, Aristide Hospital DANTEC, Dakar, Senegal., Hounto AO; 1Laboratory Service and Chemo Sensitivity, Benin National Malaria Control Program, Cotonou, Benin. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Jul 12; Vol. 105 (3), pp. 670-676. Date of Electronic Publication: 2021 Jul 12. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Antimalarials/*therapeutic use , Artemether, Lumefantrine Drug Combination/*therapeutic use , Malaria, Falciparum/*drug therapy, Benin ; Child, Preschool ; DNA, Protozoan/genetics ; Drug Resistance, Microbial/genetics ; Female ; Humans ; Infant ; Male ; Plasmodium falciparum/genetics ; Treatment Outcome |
| مستخلص: | In 2005, artemether-lumefantrine (AL), an artemisinin-based combination therapy, was introduced as the first-line treatment of uncomplicated Plasmodium falciparum malaria in Benin. Per World Health Organization recommendations to monitor the efficacy of antimalarial treatment, we conducted a therapeutic efficacy study with AL for uncomplicated P. falciparum malaria in Bohicon and Kandi, Benin, from 2018 to 2019. Febrile patients aged 6 to 59 months with confirmed P. falciparum monoinfection received supervised doses of AL for 3 days. We monitored patients clinically and parasitologically on days 1, 2, 3, 7, 14, 21, and 28. A molecular analysis to detect mutations in the P. falciparum Kelch propeller gene (Pfk13) gene was carried out on day 0 samples. A total of 205 patients were included in the study. In Bohicon, the uncorrected adequate clinical and parasitological response (ACPR) proportion was 91.3% (95% confidence interval [CI]: 84.6-95.8%), whereas in Kandi this proportion was 96.7% (95% CI: 90.6-99.3%). Genotype-corrected ACPR proportions were 96.3% (95% CI: 90.9-99.0%) and 96.7% (95% CI: 90.6-99.3%) in Bohicon and Kandi, respectively. On day 3, 100% of patients in Bohicon and 98.9% of patients in Kandi had undetectable parasitemia. The C580Y mutation in the Pfk13 gene was not observed. AL remains effective for P. falciparum malaria in these two sites in Benin. Monitoring antimalarial efficacy and prevalence of molecular-resistance markers in Benin should be continued to allow for early detection of antimalarial resistance and to guide treatment policies. |
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| المشرفين على المادة: | 0 (Antimalarials) 0 (Artemether, Lumefantrine Drug Combination) 0 (DNA, Protozoan) |
| تواريخ الأحداث: | Date Created: 20210713 Date Completed: 20211011 Latest Revision: 20220902 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8592339 |
| DOI: | 10.4269/ajtmh.21-0086 |
| PMID: | 34255739 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
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| DOI: | 10.4269/ajtmh.21-0086 |