دورية أكاديمية

New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma.

التفاصيل البيبلوغرافية
العنوان: New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma.
المؤلفون: Chang X; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, China., Ma Z; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, China., Zhu G; The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, China., Lu Y; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, China., Yang J; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, China.
المصدر: Journal of bone oncology [J Bone Oncol] 2021 Jun 23; Vol. 29, pp. 100372. Date of Electronic Publication: 2021 Jun 23 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101610292 Publication Model: eCollection Cited Medium: Print ISSN: 2212-1366 (Print) Linking ISSN: 22121366 NLM ISO Abbreviation: J Bone Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, c2012-
مستخلص: Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tumor microenvironment (TME) during the process. MSCs link to cells by acting on each component in the TME via autocrine or paracrine extracellular vesicles for cellular communication. Because of their unique characteristics, MSCs can be modified and processed into good biological carriers, loaded with drugs, and transfected with anticancer genes for the targeted treatment of osteosarcoma. Previous high-quality reviews have described the biological characteristics of MSCs; this review will discuss the effects of MSCs on the components of the TME and cellular communication and the prospects for clinical applications of MSCs.
(© 2021 The Authors. Published by Elsevier GmbH.)
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فهرسة مساهمة: Keywords: 3TSR, Three type 1 repeats; 5 FC, 5-fluorocytosine; AD-MSCs, Adipose-derived MSCs; AQP1, Aquaporin-1; BMSC-derived exosomes, BMSC-Exos; BMSCs, Bone marrow mesenchymal stem cells; CAFs, Carcinoma-associated-fibroblasts; CRC, Colorectal cancer; CSF, Colony-stimulating factor; Cellular communication; Clinical application; DOX, Doxorubicin; DP-MSCs, Dental pulp-derived MSCs, hUC-MSCs, Human umbilical cord MSCs; ECM, Extracellular matrix; ESCs, embryonic stem cells; EVs, Extracellular vesicles; GBM, Glioblastoma; HCC, hepatocellular carcinoma; LINE-1, Long interspersing element 1; MCP-1, Monocyte chemoattractant protein-1; MSC-Exos, MSC-derived exosomes; MSC-MVs, MSC microvesicles; MSCs; MSCs, Mesenchymal stem cells; OPG, osteoprotegerin; OS, osteosarcoma; Osteosarcoma; PDGFRα, Platelet derived growth factor receptor α; PDGFRβ, Platelet derived growth factor receptor β; PDGFα, Platelet derived growth factor α; S TRAIL, Secretable variant of the TNF-related apoptosis-inducing ligand; SD-MSCs, stressed MSCs; SDF-1, Stromal cell-derived factor 1; TGF, Transforming growth factor; TME; TME, Tumor microenvironment; TNF, Tumor necrosis factor; TRA2B, Transformer 2β; VEGF, Vascular endothelial growth factor; hASCs, human adipose stem cells; iPSCs, induced pluripotent stem cells; yCD::UPRT, Yeast cytosine deaminase::uracil phosphoribosyl transferase
تواريخ الأحداث: Date Created: 20210714 Latest Revision: 20210715
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8254115
DOI: 10.1016/j.jbo.2021.100372
PMID: 34258182
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-1366
DOI:10.1016/j.jbo.2021.100372