دورية أكاديمية
أعرض في EDS

Evaluation of Antiplasmodial Activity of Hydroalcoholic Crude Extract and Solvent Fractions of Zehneria scabra Roots Against Plasmodium berghei in Swiss Albino Mice.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Antiplasmodial Activity of Hydroalcoholic Crude Extract and Solvent Fractions of Zehneria scabra Roots Against Plasmodium berghei in Swiss Albino Mice.
المؤلفون: Nureye D; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Southwest Ethiopia., Tekalign E; Department of Medical Laboratory sciences, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Southwest Ethiopia., Fisseha N; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Southwest Ethiopia., Tesfaye T; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Southwest Ethiopia., Hammeso WW; Department of Pharmacology and Toxicology, School of Pharmacy, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Southwest Ethiopia.
المصدر: Infection and drug resistance [Infect Drug Resist] 2021 Jul 06; Vol. 14, pp. 2583-2596. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101550216 Publication Model: eCollection Cited Medium: Print ISSN: 1178-6973 (Print) Linking ISSN: 11786973 NLM ISO Abbreviation: Infect Drug Resist Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Auckland, N.Z. : Dove Medical Press, 2008-
مستخلص: Background: Since drug resistance makes controlling malaria parasites a major challenge, these pioneering researchers explore and discover new novel drugs from a variety of sources. As a result, this study aimed to assess the anti-plasmodial activity of hydroalcoholic crude extract and solvent fractions of Zehneria scabra roots in mice infected with Plasmodium berghei .
Methods: The antimalarial activity and safety profile of Zehneria scabra extracts were tested in a mouse model using four-day suppressive, prophylactic, and rane's tests against chloroquine-sensitive Plasmodium berghei . Mice were divided into five groups at random: group I received distilled water (10 mL/kg), group II, III, and IV received 200, 400, and 600 mg/kg of the extract, respectively, and group V received chloroquine (25 mg/kg). The antimalarial activity of the extract was determined using parasitemia levels, survival time, rectal temperature, and weight variation.
Results: At all dose levels, the crude extract and solvent fractions of Zehneria scabra showed significant ( p <0.05 to p <0.001) chemosuppression, with the crude extract and butanol fraction showing the highest chemosuppression (73.09% and 74.09%, respectively). Apart from suppressing parasitemia, the extract also increased survival time and secured packed cell volume reduction substantially ( p <0.05 to p <0.001), while the crude extract had no significant impact on body weight or rectal temperature reduction in four-day suppressive and prophylactic models.
Conclusion: The result designated that Zehneria scabra is endowed with significant antimalarial activity. These results thus support the traditional use of Zehneria scabra , for the treatment of malaria.
Competing Interests: The authors report no conflicts of interest in this work.
(© 2021 Nureye et al.)
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فهرسة مساهمة: Keywords: Plasmodium berghei; Swiss albino mice; Zehneria scabra; malaria
تواريخ الأحداث: Date Created: 20210715 Latest Revision: 20220424
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8275019
DOI: 10.2147/IDR.S314262
PMID: 34262303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-6973
DOI:10.2147/IDR.S314262