دورية أكاديمية
أعرض في EDS

Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.

التفاصيل البيبلوغرافية
العنوان: Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
المؤلفون: Izadi M; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Seemann E; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Schlobinski D; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Schwintzer L; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Qualmann B; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Kessels MM; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany.
المصدر: ELife [Elife] 2021 Jul 15; Vol. 10. Date of Electronic Publication: 2021 Jul 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Actins/*genetics , Actins/*metabolism , Microfilament Proteins/*metabolism , Neurons/*metabolism, Actin Cytoskeleton/metabolism ; Animals ; Calcium Signaling ; Calmodulin/metabolism ; Cell Membrane/metabolism ; Cytoskeletal Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/genetics ; Protein Binding ; Rats
مستخلص: Local actin filament formation is indispensable for development of the dendritic arbor of neurons. We show that, surprisingly, the action of single actin filament-promoting factors was insufficient for powering dendritogenesis. Instead, this required the actin nucleator Cobl and its only evolutionary distant ancestor Cobl-like acting interdependently. This coordination between Cobl-like and Cobl was achieved by physical linkage by syndapins. Syndapin I formed nanodomains at convex plasma membrane areas at the base of protrusive structures and interacted with three motifs in Cobl-like, one of which was Ca 2+ /calmodulin-regulated. Consistently, syndapin I, Cobl-like's newly identified N terminal calmodulin-binding site and the single Ca 2+ /calmodulin-responsive syndapin-binding motif all were critical for Cobl-like's functions. In dendritic arbor development, local Ca 2+ /CaM-controlled actin dynamics thus relies on regulated and physically coordinated interactions of different F-actin formation-promoting factors and only together they have the power to bring about the sophisticated neuronal morphologies required for neuronal network formation in mammals.
Competing Interests: MI, ES, DS, LS, BQ, MK No competing interests declared
(© 2021, Izadi et al.)
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فهرسة مساهمة: Keywords: Ca2+-steered; F-BAR domain protein syndapin I; F-actin-supported neuronal morphogenesis; actin nucleators; cell biology; dendritic branch initiation sites; development of the dendritic arbor of neurons; functional cooperation of actin nucleators; mouse; neuroscience; rat
المشرفين على المادة: 0 (Actins)
0 (Calmodulin)
0 (Cobl protein, mouse)
0 (Cytoskeletal Proteins)
0 (Microfilament Proteins)
تواريخ الأحداث: Date Created: 20210715 Date Completed: 20211101 Latest Revision: 20211101
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8282341
DOI: 10.7554/eLife.67718
PMID: 34264190
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.67718