دورية أكاديمية
Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
العنوان: | Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development. |
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المؤلفون: | Izadi M; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Seemann E; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Schlobinski D; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Schwintzer L; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Qualmann B; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany., Kessels MM; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. |
المصدر: | ELife [Elife] 2021 Jul 15; Vol. 10. Date of Electronic Publication: 2021 Jul 15. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Actins/*genetics , Actins/*metabolism , Microfilament Proteins/*metabolism , Neurons/*metabolism, Actin Cytoskeleton/metabolism ; Animals ; Calcium Signaling ; Calmodulin/metabolism ; Cell Membrane/metabolism ; Cytoskeletal Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/genetics ; Protein Binding ; Rats |
مستخلص: | Local actin filament formation is indispensable for development of the dendritic arbor of neurons. We show that, surprisingly, the action of single actin filament-promoting factors was insufficient for powering dendritogenesis. Instead, this required the actin nucleator Cobl and its only evolutionary distant ancestor Cobl-like acting interdependently. This coordination between Cobl-like and Cobl was achieved by physical linkage by syndapins. Syndapin I formed nanodomains at convex plasma membrane areas at the base of protrusive structures and interacted with three motifs in Cobl-like, one of which was Ca 2+ /calmodulin-regulated. Consistently, syndapin I, Cobl-like's newly identified N terminal calmodulin-binding site and the single Ca 2+ /calmodulin-responsive syndapin-binding motif all were critical for Cobl-like's functions. In dendritic arbor development, local Ca 2+ /CaM-controlled actin dynamics thus relies on regulated and physically coordinated interactions of different F-actin formation-promoting factors and only together they have the power to bring about the sophisticated neuronal morphologies required for neuronal network formation in mammals. Competing Interests: MI, ES, DS, LS, BQ, MK No competing interests declared (© 2021, Izadi et al.) |
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فهرسة مساهمة: | Keywords: Ca2+-steered; F-BAR domain protein syndapin I; F-actin-supported neuronal morphogenesis; actin nucleators; cell biology; dendritic branch initiation sites; development of the dendritic arbor of neurons; functional cooperation of actin nucleators; mouse; neuroscience; rat |
المشرفين على المادة: | 0 (Actins) 0 (Calmodulin) 0 (Cobl protein, mouse) 0 (Cytoskeletal Proteins) 0 (Microfilament Proteins) |
تواريخ الأحداث: | Date Created: 20210715 Date Completed: 20211101 Latest Revision: 20211101 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8282341 |
DOI: | 10.7554/eLife.67718 |
PMID: | 34264190 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.67718 |