دورية أكاديمية
Differential effects of β-methylphenylethylamine and octopamine on contractile parameters of the rat gastrointestinal tract.
العنوان: | Differential effects of β-methylphenylethylamine and octopamine on contractile parameters of the rat gastrointestinal tract. |
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المؤلفون: | de Oliveira DMN; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Oliveira-Silva CA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Pinheiro CG; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., de Carvalho EF; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Gadelha KKL; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Lima-Silva K; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Cavalcante AKM; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Belém MO; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Paula SM; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Dos Santos AA; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil., Magalhães PJC; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: pjcmagal@ufc.br. |
المصدر: | European journal of pharmacology [Eur J Pharmacol] 2021 Oct 05; Vol. 908, pp. 174339. Date of Electronic Publication: 2021 Jul 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
مواضيع طبية MeSH: | Amphetamines* , Octopamine*, Animals ; Gastric Fundus ; Muscle Contraction ; Muscle Relaxation ; Muscle, Smooth ; Rats ; Receptors, Serotonin |
مستخلص: | This study tested the effects of β-methylphenylethylamine (β-MPEA) and octopamine on contractile parameters of the gastrointestinal tract in rats. We hypothesized that some of their effects result from interactions with trace amine (TA)-associated receptors or serotoninergic 5-hydroxytryptamine (5-HT) receptors. β-MPEA-induced contractions in rat gastric fundus strips under resting tonus conditions, but induced relaxation in preparations that were previously contracted with carbachol. Octopamine relaxed gastric fundus strips maintained at resting tonus or contracted with carbachol. The contractile effect of β-MPEA was reduced by cyproheptadine and methiothepin, antagonists of excitatory 5-HT receptors. The relaxing effect of β-MPEA on gastric fundus was insensitive to pretreatment with N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide (EPPTB) and tropisetron, antagonists of TA (Copyright © 2021 Elsevier B.V. All rights reserved.) |
فهرسة مساهمة: | Keywords: 5-HT receptors; Gastrointestinal transit; Phenethylamines; Trace amine-associated receptors |
المشرفين على المادة: | 0 (Amphetamines) 0 (Receptors, Serotonin) 0 (beta-methylphenyl-ethylamine) 14O50WS8JD (Octopamine) |
تواريخ الأحداث: | Date Created: 20210715 Date Completed: 20220106 Latest Revision: 20220106 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.ejphar.2021.174339 |
PMID: | 34265293 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-0712 |
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DOI: | 10.1016/j.ejphar.2021.174339 |