دورية أكاديمية
Pera orange (Citrus sinensis) and Moro orange (Citrus sinensis (L.) Osbeck) juices attenuate left ventricular dysfunction and oxidative stress and improve myocardial energy metabolism in acute doxorubicin-induced cardiotoxicity in rats.
| العنوان: | Pera orange (Citrus sinensis) and Moro orange (Citrus sinensis (L.) Osbeck) juices attenuate left ventricular dysfunction and oxidative stress and improve myocardial energy metabolism in acute doxorubicin-induced cardiotoxicity in rats. |
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| المؤلفون: | Ribeiro APD; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Pereira AG; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil. Electronic address: ag.pereira@unesp.br., Todo MC; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Fujimori ASS; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Dos Santos PP; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Dantas D; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Fernandes AA; Chemistry and Biochemistry Department, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, Brazil., Zanati SG; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Hassimotto NMA; Department of Food Science and Experimental Nutrition, School of Pharmaceutical Science, University of São Paulo, São Paulo, Brazil., Zornoff LAM; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Azevedo PS; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Minicucci MF; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Paiva SAR; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., Polegato BF; Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil. |
| المصدر: | Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2021 Nov-Dec; Vol. 91-92, pp. 111350. Date of Electronic Publication: 2021 Jun 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: [Burbank, Calif. : Nutrition, c1987- |
| مواضيع طبية MeSH: | Citrus sinensis* , Ventricular Dysfunction, Left*/chemically induced, Animals ; Cardiotoxicity/etiology ; Doxorubicin/toxicity ; Energy Metabolism ; Male ; Oxidative Stress ; Rats ; Rats, Wistar |
| مستخلص: | Objectives: Doxorubicin is a highly effective chemotherapeutic agent for treating several types of cancer; however, it can induce cardiotoxicity. We evaluated the influence of Pera and Moro orange juices on cardiac remodeling induced by acute administration of doxorubicin in rats. Methods: We allocated 120 male Wistar rats into six groups: control (C), Pera orange juice (PO), Moro orange juice (MO), doxorubicin (D), doxorubicin + Pera orange juice (DPO), and doxorubicin + Moro orange juice (DMO). Groups PO and DPO received Pera orange juice, MO and DMO received Moro orange juice, and C and D received water with maltodextrin (100 g/L) for 4 wk. Subsequently, groups D, DPO, and DMO received 20 mg/kg doxorubicin and C, PO, and MO received saline. Echocardiogram and euthanasia were performed 48 h after doxorubicin injection. Juice and animal-serum flavonoid identification and quantification were evaluated by liquid chromatography/electrospray ionization multistage mass spectrometry. Oxidative stress and myocardial metabolism were evaluated by spectrophotometry. Results: Systolic and diastolic left ventricular dysfunction increased oxidative stress and pathologic changes in myocardial energy metabolism of rats treated with doxorubicin. Intake of both orange juices improved left ventricular function, decreased oxidative stress, and attenuated the myocardial energy metabolism changes. Moro orange juice had a more pronounced effect than Pera orange juice in glutathione peroxidase activity, citrate synthase, and β-hydroxyacyl-CoA dehydrogenase activity. Conclusions: Pera and Moro orange juices attenuated cardiac remodeling induced by doxorubicin, improved myocardial energy metabolism, and attenuated oxidative stress. However, Moro orange juice was more effective than Pera orange juice in modifying energy metabolism. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Citrate synthase; Glutathione peroxidase; Lipid hydroperoxide; Mitochondrial respiratory chain; β-Hydroxyacyl-CoA dehydrogenase |
| المشرفين على المادة: | 80168379AG (Doxorubicin) |
| تواريخ الأحداث: | Date Created: 20210715 Date Completed: 20211209 Latest Revision: 20211214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.nut.2021.111350 |
| PMID: | 34265580 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-1244 |
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| DOI: | 10.1016/j.nut.2021.111350 |