Comparative Effectiveness of a Six-Week Treatment Course of Vitamin D 2 and D 3 in Children With Sickle Cell Anemia in Steady State With Hypovitaminosis D: A Randomized Clinical Trial.

التفاصيل البيبلوغرافية
العنوان:	Comparative Effectiveness of a Six-Week Treatment Course of Vitamin D 2 and D 3 in Children With Sickle Cell Anemia in Steady State With Hypovitaminosis D: A Randomized Clinical Trial.
المؤلفون:	Adekunle MO; Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria., Dada AO; Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Njokanma FO; Department of Paediatrics and Child Health, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Solarin AU; Department of Paediatrics and Child Health, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Animasahun BA; Department of Paediatrics and Child Health, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria., Lamina MO; Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.
المصدر:	Journal of hematology [J Hematol] 2021 Jun; Vol. 10 (3), pp. 114-122. Date of Electronic Publication: 2021 Jun 16.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Elmer Press, Inc Country of Publication: Canada NLM ID: 101635099 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1927-1220 (Electronic) Linking ISSN: 19271212 NLM ISO Abbreviation: J Hematol Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: [Brossard, Quebec] : Elmer Press, Inc., [2012]-
مستخلص:	Background: Correction of vitamin D deficiency through administration of either vitamin D 2 or D 3 has been shown to reduce chronic bone pains and frequency of acute bone pains, increase bone density as well as improve growth stature in children with sickle cell anemia (SCA). Findings vary on the effectiveness of the two forms of the vitamin. The current study was carried out to compare the effectiveness of a 6-week treatment course of vitamin D 2 and D 3 in the correction of hypovitaminosis D (vitamin D insufficiency and deficiency) as well as evaluate treatment response to derangement of serum calcium and alkaline phosphatase (ALP) in children with SCA in steady state. Methods: The study was a randomized, double-blind clinical trial of 174 children with SCA aged 1 - 18 years. Subjects with hypovitaminosis D (baseline serum 25-hydroxyvitamin D (25(OH)D) below 75 nmol/L) were randomized into two treatment arms. Each arm treated either of the two forms of vitamin D had a once weekly dose of 50,000 IU for a period of 6 weeks. Results: Median rise in serum 25(OH)D after 6 weeks of oral vitamin D 2 or D 3 was similar between the two groups (median rise in 25(OH)D of 17.8 nmol/L in D 2 , 15.3 nmol/L in D 3 groups). Also, there was no significant difference in the proportion of subjects that improved in their vitamin D status in both treatment arms (P = 0.409). Treatment was significantly associated with increase in proportion of subjects with normal serum calcium (P ≤ 0.001) and decrease in proportion of subjects with elevated serum ALP (P ≤ 0.001). Conclusion: Once weekly dose (50,000 IU) of either vitamin D supplement has equal effectiveness in correction of hypovitaminosis D. However, vitamin D 3 may be cost-effective because it is cheaper. Competing Interests: No conflict of interest among the authors. (Copyright 2021, Adekunle et al.)
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فهرسة مساهمة:	Keywords: 25(OH)D; Drug effectiveness; Hypovitaminosis D; Sickle cell anemia; Six-week course
تواريخ الأحداث:	Date Created: 20210716 Latest Revision: 20220424
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC8256915
DOI:	10.14740/jh817
PMID:	34267848
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1927-1220
DOI:	10.14740/jh817