دورية أكاديمية
Combining sonodynamic therapy with chemoradiation for the treatment of pancreatic cancer.
| العنوان: | Combining sonodynamic therapy with chemoradiation for the treatment of pancreatic cancer. |
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| المؤلفون: | Browning RJ; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Able S; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Ruan JL; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Bau L; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK., Allen PD; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Kersemans V; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Wallington S; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Kinchesh P; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Smart S; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK., Kartsonaki C; MRC Population Health Research Unit, Clinical Trials Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7DQ, UK., Kamila S; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK., Logan K; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK., Taylor MA; Department of HPB Surgery, Mater Hospital, Belfast, Northern Ireland BT14 6AB, UK., McHale AP; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK., Callan JF; Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK., Stride E; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK., Vallis KA; Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: katherine.vallis@oncology.ox.ac.uk. |
| المصدر: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Sep 10; Vol. 337, pp. 371-377. Date of Electronic Publication: 2021 Jul 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| مواضيع طبية MeSH: | Pancreatic Neoplasms*/drug therapy , Photochemotherapy* , Ultrasonic Therapy*, Animals ; Fluorouracil/therapeutic use ; Humans ; Mice ; Reactive Oxygen Species |
| مستخلص: | Treatment options for patients with pancreatic cancer are limited and survival prospects have barely changed over the past 4 decades. Chemoradiation treatment (CRT) has been used as neoadjuvant therapy in patients with borderline resectable disease to reduce tumour burden and increase the proportion of patients eligible for surgery. Antimetabolite drugs such as gemcitabine and 5-fluorouracil are known to sensitise pancreatic tumours to radiation treatment. Likewise, photodynamic therapy (PDT) has also been shown to enhance the effect of radiation therapy. However, PDT is limited to treating superficial lesions due to the attenuation of light by tissue. The ability of the related technique, sonodynamic therapy (SDT), to enhance CRT was investigated in two murine models of pancreatic cancer (PSN-1 and BxPC-3) in this study. SDT uses low intensity ultrasound to activate an otherwise non-toxic sensitiser, generating toxic levels of reactive oxygen species (ROS) locally. It is applicable to greater target depths than PDT due to the ability of ultrasound to propagate further than light in tissue. Both CRT and the combination of CRT plus SDT delayed tumour growth in the two tumour models. In the PSN-1 model, but not the BxPC-3 model, the combination treatment caused an increase in survival relative to CRT alone (p = 0.038). The improvement in survival conferred by the addition of SDT in this model may be related to differences in tumour architecture between the two models. MRI and US images showed that PSN-1 tumours were less well perfused and vascularised than BxPC-3 tumours. This poor vascularisation may explain why PSN-1 tumours were more susceptible to the effects of vascular damage exerted by SDT treatment. (Copyright © 2021. Published by Elsevier B.V.) |
| معلومات مُعتمدة: | C5255/A15935 United Kingdom CRUK_ Cancer Research UK; 16896 United Kingdom CRUK_ Cancer Research UK; 16466 United Kingdom CRUK_ Cancer Research UK; C5255/A16466 United Kingdom CRUK_ Cancer Research UK; 22906 United Kingdom CRUK_ Cancer Research UK; 28736 United Kingdom CRUK_ Cancer Research UK |
| فهرسة مساهمة: | Keywords: Chemoradiotherapy; Oxygen microbubbles; Pancreatic cancer; Sonodynamic therapy; Ultrasound |
| المشرفين على المادة: | 0 (Reactive Oxygen Species) U3P01618RT (Fluorouracil) |
| تواريخ الأحداث: | Date Created: 20210718 Date Completed: 20211028 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| DOI: | 10.1016/j.jconrel.2021.07.020 |
| PMID: | 34274382 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4995 |
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| DOI: | 10.1016/j.jconrel.2021.07.020 |