دورية أكاديمية
أعرض في EDS

Clinical outcomes and costs of the use of fibrin sealant in pancreaticojejunal anastomosis after pancreaticoduodenectomy: a retrospective analysis study.

التفاصيل البيبلوغرافية
العنوان: Clinical outcomes and costs of the use of fibrin sealant in pancreaticojejunal anastomosis after pancreaticoduodenectomy: a retrospective analysis study.
المؤلفون: Gaspar AF; Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Kemp R; Division of Gastrointestinal Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Sankarankutty AK; Division of Gastrointestinal Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Júnior JRL; Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Filho JAF; Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Martone D; Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Mota GA; Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil., Santos JSD; Division of Gastrointestinal Surgery, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
المصدر: Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2021 Jun 29; Vol. 67, pp. 102531. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Country of Publication: England NLM ID: 101616869 Publication Model: eCollection Cited Medium: Print ISSN: 2049-0801 (Print) Linking ISSN: 20490801 NLM ISO Abbreviation: Ann Med Surg (Lond) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : [London] : Wolters Kluwer
Original Publication: London : Surgical Associates Ltd., 2012-
مستخلص: Objectives: The benefits of using a fibrin sealant to reinforce the pancreaticojejunal anastomosis are still contentious, a fact that justifies the study of its effects on clinical outcomes and costs of pancreaticoduodenectomy.
Methods: Study of 62 consecutive patients submitted to pancreaticoduodenectomy, divided into two groups of 31 patients each: GWS = group with sealant and GWOS = group without sealant that were compared according to demographic, clinical, laboratory aspects, the incidence of postoperative pancreatic fistula (POPF), according to the definition of the International Study Group on Pancreatic Fistula, updated in 2016, and its postoperative complications categorized according to the Clavien classification, as well as hospital costs evaluated by the absorption costing method (with the exception of those related to medications).
Results: The groups were homogeneous and there were no significant differences in the postoperative clinical course or in the indicators of hospital care between them. Hard texture of pancreatic tissue was the only protective factor against the development of POPF (RR = 0.29 (95%CI:0,12-0,68); p = 0.005). Moreover, hospital costs were higher in GWS than in GWOS (p < 0.0001).
Conclusions: The use of fibrin sealant to reinforce pancreaticojejunal anastomosis did not improve the clinical and healthcare outcomes and, in addition, increased hospital costs.
Competing Interests: No conflicts of interest.
(© 2021 The Authors.)
References: Surgery. 2006 Jun;139(6):735-42. (PMID: 16782427)
J Cardiovasc Surg (Torino). 2007 Jun;48(3):323-31. (PMID: 17505437)
J Bone Joint Surg Am. 1999 Nov;81(11):1580-8. (PMID: 10565650)
Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542)
Cir Esp. 2012 Apr;90(4):222-32. (PMID: 22036176)
Int J Surg. 2019 Dec;72:156-165. (PMID: 31704426)
Br J Surg. 2018 Jun;105(7):811-819. (PMID: 29664999)
J Gastrointest Surg. 2006 Nov;10(9):1280-90; discussion 1290. (PMID: 17114014)
J Gastrointest Surg. 2007 Oct;11(10):1242-51; discussion 1251-2. (PMID: 17694419)
Cochrane Database Syst Rev. 2018 Jun 23;6:CD009621. (PMID: 29934987)
World J Gastroenterol. 2008 Oct 14;14(38):5789-96. (PMID: 18855976)
Acta Cir Bras. 2008;23 Suppl 1:133-42; discussion 142. (PMID: 18516461)
Surgery. 2017 Mar;161(3):584-591. (PMID: 28040257)
J Gastrointest Surg. 2004 Nov;8(7):766-72; discussion 772-4. (PMID: 15531229)
Ann Surg. 2007 Mar;245(3):443-51. (PMID: 17435552)
World J Surg. 2010 Apr;34(4):632-4. (PMID: 19820991)
Ann Surg. 2006 Jul;244(1):1-7. (PMID: 16794381)
Surgery. 2003 Nov;134(5):766-71. (PMID: 14639354)
J Gastrointest Surg. 2006 Nov;10(9):1199-210; discussion 1210-1. (PMID: 17114007)
Ann Surg. 2006 Dec;244(6):931-7; discussion 937-9. (PMID: 17122618)
Hepatogastroenterology. 2005 Jan-Feb;52(61):45-7. (PMID: 15782991)
Cochrane Database Syst Rev. 2012 Jun 13;(6):CD008370. (PMID: 22696379)
HPB (Oxford). 2013 Aug;15(8):561-6. (PMID: 23458447)
HPB (Oxford). 2014 Jan;16(1):3-11. (PMID: 23461684)
Int J Surg. 2015 Sep;21 Suppl 1:S4-9. (PMID: 26118602)
Pancreas. 2014 Apr;43(3):445-50. (PMID: 24622077)
Am J Surg. 2009 Jun;197(6):702-9. (PMID: 18778804)
Ann Surg. 2000 Sep;232(3):419-29. (PMID: 10973392)
Gut. 2005 Jun;54 Suppl 5:v1-16. (PMID: 15888770)
Dig Surg. 2012;29(1):54-61. (PMID: 22441621)
فهرسة مساهمة: Keywords: Fibrin sealant; Healthcare costs; Pancreatic fistula; Pancreaticoduodenectomy
تواريخ الأحداث: Date Created: 20210719 Latest Revision: 20220424
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8267440
DOI: 10.1016/j.amsu.2021.102531
PMID: 34276983
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-0801
DOI:10.1016/j.amsu.2021.102531