دورية أكاديمية
أعرض في EDS

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.

التفاصيل البيبلوغرافية
العنوان: Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts.
المؤلفون: Magaye RR; Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia., Savira F; Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia., Xiong X; Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia.; Shanghai Institute of Heart Failure, Research Centre for Translational Medicine, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, PR China., Huynh K; Metabolomics Research Group, Baker Heart and Diabetes Institute, Melbourne, Australia., Meikle PJ; Metabolomics Research Group, Baker Heart and Diabetes Institute, Melbourne, Australia.; School of Public Health School, Curtin University, Perth, Australia., Reid C; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia.; School of Public Health School, Curtin University, Perth, Australia., Flynn BL; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia., Kaye D; Heart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, Australia., Liew D; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia., Wang BH; Biomarker Discovery Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.; Monash Centre of Cardiovascular Research and Education in Therapeutics, Melbourne, Australia.
المصدر: International journal of cardiology. Heart & vasculature [Int J Cardiol Heart Vasc] 2021 Jul 06; Vol. 35, pp. 100837. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101649525 Publication Model: eCollection Cited Medium: Print ISSN: 2352-9067 (Print) Linking ISSN: 23529067 NLM ISO Abbreviation: Int J Cardiol Heart Vasc Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Shannon [Ireland] : Elsevier Ireland Ltd., [2014]-
مستخلص: The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being investigated for their role in diseases and as potential therapeutic targets. The intermediate sphingolipids such as dihydrosphingosine (dhSph) and sphingosine (Sph) have not been investigated due to them being thought of as precursors to other more active lipids such as ceramide (Cer) and sphingosine 1 phosphate (S1P). Here we investigated their effects in terms of collagen synthesis in primary rat neonatal cardiac fibroblasts (NCFs). Our results in NCFs showed that both dhSph and Sph did not induce collagen synthesis, whilst dhSph reduced collagen synthesis induced by transforming growth factor β (TGFβ). The mechanisms of these inhibitory effects were associated with the increased activation of the de novo synthesis pathway that led to increased dihydrosphingosine 1 phosphate (dhS1P). Subsequently, through a negative feedback mechanism that may involve substrate-enzyme receptor interactions, S1P receptor 1 expression (S1PR1) was reduced.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 The Authors. Published by Elsevier B.V.)
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فهرسة مساهمة: Keywords: Akt, protein kinase B; CTGF, connective tissue growth factor; Cardiac fibroblasts; Cer, ceramide; Cer1P, ceramide 1 phosphate; Coll1a1, collagen 1a1; Collagen synthesis; Degs1, dihydroceramide desaturase 1 gene; Des-1, dihydroceramide desaturase 1 enzyme; Dihydrosphingosine; ECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα/β); MA3PK, mitogen activated protein kinase kinase kinase; MAPK, mitogren activated protein kinase; MI, myocardial infarct; MMP2, matrix metalloproteinase 2; NCF, neonatal cardiac fibroblasts; RPS6, ribosomal protein S6; S1P, sphingosine-1 Phosphate; S1PR1, sphingosine -1-phosphate receptor 1; S1PRs, sphingosine 1 phosphate receptor 1-5; SK1, sphingosine kinase 1; Sph, sphingosine; Sphingolipid; TAK1, transforming growth factor β activating kinase 1; TGFβ; TGFβ, transforming growth factor β; TIMP1, tissue inhibitor of metalloproteinase 1; d7dhSph, deuterated dihydrosphingosine; dhCer, dihydroceramide; dhS1P, dihydrosphingosine 1 phosphate; mTOR, mammalian target for rapamycin
تواريخ الأحداث: Date Created: 20210719 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8264607
DOI: 10.1016/j.ijcha.2021.100837
PMID: 34277924
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-9067
DOI:10.1016/j.ijcha.2021.100837