دورية أكاديمية
Spectrum of Clinical Presentation of Celiac Disease in Pediatric Population.
| العنوان: | Spectrum of Clinical Presentation of Celiac Disease in Pediatric Population. |
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| المؤلفون: | Imran; Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital and The Institute of Child Health, Lahore, PAK., Cheema HA; Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital and The Institute of Child Health, Lahore, PAK., Alvi MA; Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital and The Institute of Child Health, Lahore, PAK., Rehman MU; Pediatric Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK., Ali M; Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital and The Institute of Child Health, Lahore, PAK., Sarwar HA; Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital and The Institute of Child Health, Lahore, PAK. |
| المصدر: | Cureus [Cureus] 2021 Jun 10; Vol. 13 (6), pp. e15582. Date of Electronic Publication: 2021 Jun 10 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
| مستخلص: | Background Classic form of celiac disease (CCD) presents with diarrhea and is traditionally taught as malabsorption syndrome. This form of CD is diagnosed with ease but non-classical form presenting without diarrhea is often missed and heavily underdiagnosed. Objective To determine the clinical spectrum of patients with CD. Methods This study was conducted in the Department of Gastroenterology & Hepatology at the Children's Hospital, Lahore. Confirmed CD children according to NASPGHAN (North American Society of Pediatric Gastroenterology, Hepatology & Nutrition) criteria were enrolled in this study from June to September, 2020. Initial positivity followed by small bowel biopsy with Modified Marsh 2 and above is considered consistent with the diagnosis of CD. Results A total of 90 patients were selected according to NASPGHAN criteria, 77 (85.6%) patients had CCD whereas 13 (14.4%) patients had non-classical CD (NCCD). The mean ± SD age at diagnosis of CCD was 2.6 ± 2.3 years whereas mean ± SD in NCCD was 9 ± 1.8 years. Females clearly predominate in our cohort in general. Chronic diarrhea followed by failure to thrive (85%) were the most common symptoms in CCD whereas short stature (69%) was the most frequent feature in NCCD. Among CD patients, tissue transglutaminase-immunoglobulin A (TTG-IgA) titre was significantly high (>10 times) in 80% of CD patients and the rest had positivity but not up to 10 times. There was no significant difference in titre of anti-TTG between CCD and NCCD. Conclusion Classical CD is still the most common in developing countries like Pakistan. High index of suspicion of CD should be maintained for patients who present with short stature, recurrent abdominal pain and refractory anemia. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, . et al.) |
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| فهرسة مساهمة: | Keywords: classic celiac disease; clinical spectrum; non classic celiac disease |
| تواريخ الأحداث: | Date Created: 20210719 Latest Revision: 20210721 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8270062 |
| DOI: | 10.7759/cureus.15582 |
| PMID: | 34279518 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2168-8184 |
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| DOI: | 10.7759/cureus.15582 |