دورية أكاديمية
أعرض في EDS

Hypoactive Thalamic Crh+ Cells in a Female Mouse Model of Alcohol Drinking After Social Trauma.

التفاصيل البيبلوغرافية
العنوان: Hypoactive Thalamic Crh+ Cells in a Female Mouse Model of Alcohol Drinking After Social Trauma.
المؤلفون: Newman EL; Department of Psychology, Tufts University, Medford, Massachusetts; Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts., Covington HE 3rd; Department of Psychology, Tufts University, Medford, Massachusetts., Leonard MZ; Department of Psychology, Tufts University, Medford, Massachusetts., Burk K; Department of Psychology, Tufts University, Medford, Massachusetts., Miczek KA; Department of Psychology, Tufts University, Medford, Massachusetts; Department of Neuroscience, Tufts University, Boston, Massachusetts. Electronic address: Klaus.miczek@tufts.edu.
المصدر: Biological psychiatry [Biol Psychiatry] 2021 Oct 15; Vol. 90 (8), pp. 563-574. Date of Electronic Publication: 2021 Jun 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Alcoholism*, Alcohol Drinking ; Animals ; Corticotropin-Releasing Hormone ; Ethanol ; Female ; Humans ; Mice ; Receptors, Corticotropin-Releasing Hormone ; Stress, Psychological
مستخلص: Background: Comorbid stress-induced mood and alcohol use disorders are increasingly prevalent among female patients. Stress exposure can disrupt salience processing and goal-directed decision making, contributing to persistent maladaptive behavioral patterns; these and other stress-sensitive cognitive and behavioral processes rely on dynamic and coordinated signaling by midline and intralaminar thalamic nuclei. Considering the role of social trauma in the trajectory of these debilitating psychopathologies, identifying vulnerable thalamic cells may provide guidance for targeting persistent stress-induced symptoms.
Methods: A novel behavioral protocol traced the progression from social trauma to the development of social defensiveness and chronically escalated alcohol consumption in female mice. Recent cell activation-measured as cFos-was quantified in thalamic cells after safe social interactions, revealing stress-sensitive corticotropin-releasing hormone-expressing (Crh+) anterior central medial thalamic (aCMT) cells. These cells were optogenetically stimulated during stress-induced social defensiveness and abstinence-escalated binge drinking.
Results: Crh+ aCMT neurons exhibited substantial activation after social interactions in stress-naïve but not in stressed female mice. Photoactivating Crh+ aCMT cells dampened stress-induced social deficits, whereas inhibiting these cells increased social defensiveness in stress-naïve mice. Optogenetically activating Crh+ aCMT cells diminished abstinence-escalated binge alcohol drinking in female mice, regardless of stress history.
Conclusions: This work uncovers a role for Crh+ aCMT neurons in maladaptive stress-induced social interactions and in binge drinking after forced abstinence in female mice. This molecularly defined thalamic cell population may serve as a critical stress-sensitive hub for social deficits caused by exposure to social trauma and for patterns of excessive alcohol drinking in female populations.
(Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Biol Psychiatry. 2021 Oct 15;90(8):513-515. (PMID: 34556205)
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معلومات مُعتمدة: F31 AA025827 United States AA NIAAA NIH HHS; F32 MH125634 United States MH NIMH NIH HHS; R01 AA013983 United States AA NIAAA NIH HHS; R01 DA031734 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: Alcohol; Corticotropin-releasing hormone; Defensive behavior; Female chronic social defeat stress; Social interaction; Thalamus
المشرفين على المادة: 0 (Receptors, Corticotropin-Releasing Hormone)
3K9958V90M (Ethanol)
9015-71-8 (Corticotropin-Releasing Hormone)
تواريخ الأحداث: Date Created: 20210720 Date Completed: 20211101 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC8463500
DOI: 10.1016/j.biopsych.2021.05.022
PMID: 34281710
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2402
DOI:10.1016/j.biopsych.2021.05.022