دورية أكاديمية
Identification of High-Mobility Group Box 1 (HMGB1) Expression as a Potential Predictor of Rejection and Poor Prognosis After Liver Transplantation.
| العنوان: | Identification of High-Mobility Group Box 1 (HMGB1) Expression as a Potential Predictor of Rejection and Poor Prognosis After Liver Transplantation. |
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| المؤلفون: | Ye Z; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China (mainland)., Jia J; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China (mainland)., Lv Z; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China (mainland)., Zheng S; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang, China (mainland). |
| المصدر: | Annals of transplantation [Ann Transplant] 2021 Jul 20; Vol. 26, pp. e931625. Date of Electronic Publication: 2021 Jul 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Scientific Literature, Inc Country of Publication: United States NLM ID: 9802544 Publication Model: Electronic Cited Medium: Internet ISSN: 2329-0358 (Electronic) Linking ISSN: 14259524 NLM ISO Abbreviation: Ann Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013- > : Smithtown, New York: International Scientific Literature, Inc. Original Publication: Warsaw : Polish Transplantology Foundation : Transplantation Institute, Warsaw Medical School, 1996- |
| مواضيع طبية MeSH: | Graft Rejection*/diagnosis , HMGB1 Protein*/metabolism , Liver Transplantation*, Adult ; Biomarkers ; End Stage Liver Disease ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Severity of Illness Index ; Young Adult |
| مستخلص: | BACKGROUND Acute cellular rejection (ACR) frequently occurs after liver transplantation (LT) and can result in permanent damage of the liver allograft. Specific and sensitive biomarkers for predicting and monitoring ACR are vital for guiding post-transplantation care. In the present study, we aimed to investigate the function of high-mobility group box 1 (HMGB1) in predicting ACR and prognosis after LT. MATERIAL AND METHODS A total of 113 LT recipients were enrolled in the study, including 62 patients in an ACR group and 51 patients in a non-rejection group. Using tissues from the 113 patients, HMGB1 expression was examined by immunohistochemistry, and the total score for HMGB1 expression was calculated by multiplying the percentage of immunoreactive cells score and the staining intensity score. We then analyzed the association between HMGB1 expression and clinical features. Finally, the function of HMGB1 in predicting the prognosis of LT was determined using Kaplan-Meier (K-M) survival and Cox multivariate analyses. RESULTS Immunohistochemical staining results demonstrated that the expression of HMGB1 was significantly increased in the ACR group, compared with that in the non-rejection group (P<0.05). Clinical characteristic analysis revealed that high HMGB1 levels were related to ACR (P<0.05). Moreover, K-M survival analysis showed that patients with high HMGB1 expression displayed poorer prognosis (P<0.05). Cox multivariate analysis demonstrated that HMGB1 was an independent prognostic predictor for post-LT survival (odds ratio, 3.283; P=0.008). CONCLUSIONS LT recipients' HMGB1 levels may be a useful and noninvasive biomarker for the prediction of ACR and prognosis after LT. |
| References: | Semin Liver Dis. 1992 Feb;12(1):28-40. (PMID: 1570549) Blood. 2005 Jul 15;106(2):609-16. (PMID: 15802534) Liver Transpl Surg. 1995 Jan;1(1):10-5. (PMID: 9346535) J Intern Med. 2004 Mar;255(3):332-43. (PMID: 14871457) Am J Transl Res. 2016 Oct 15;8(10):4054-4067. (PMID: 27829992) Am J Physiol Cell Physiol. 2006 Mar;290(3):C917-24. (PMID: 16267105) Transplantation. 2004 May 27;77(10):1595-603. (PMID: 15239628) Nat Rev Immunol. 2004 Jun;4(6):469-78. (PMID: 15173835) J Exp Med. 2005 Apr 4;201(7):1135-43. (PMID: 15795240) Med Clin North Am. 2016 May;100(3):477-86. (PMID: 27095640) Clin Transplant. 2004 Apr;18(2):152-5. (PMID: 15016129) Transpl Int. 2016 Sep;29(9):961-73. (PMID: 26714264) Hepatobiliary Pancreat Dis Int. 2019 Dec;18(6):517-524. (PMID: 31151807) Liver Transpl. 2008 Oct;14(10):1517-25. (PMID: 18825712) J Immunol. 2005 Jun 15;174(12):7506-15. (PMID: 15944249) Annu Rev Immunol. 2011;29:139-62. (PMID: 21219181) Sci Rep. 2017 Apr 06;7:46272. (PMID: 28382970) Science. 1999 Jul 9;285(5425):248-51. (PMID: 10398600) J Biol Chem. 2004 Feb 27;279(9):7370-7. (PMID: 14660645) Redox Biol. 2017 Oct;13:600-607. (PMID: 28806702) J Clin Exp Hepatol. 2017 Dec;7(4):358-366. (PMID: 29234201) Fish Shellfish Immunol. 2014 Feb;36(2):393-400. (PMID: 24378681) Curr Opin Organ Transplant. 2011 Oct;16(5):499-504. (PMID: 21897246) Transpl Immunol. 2008 May;19(2):87-92. (PMID: 18503883) Nat Rev Immunol. 2005 Apr;5(4):331-42. (PMID: 15803152) Transpl Immunol. 2018 Apr;47:1-9. (PMID: 29452168) Hepatology. 2014 May;59(5):1984-1997. (PMID: 24375466) Am J Transplant. 2015 Aug;15(8):2062-74. (PMID: 25943147) Annu Rev Immunol. 2010;28:367-88. (PMID: 20192808) J Cell Mol Med. 2019 Apr;23(4):2849-2862. (PMID: 30784177) Expert Opin Ther Targets. 2018 Mar;22(3):263-277. (PMID: 29447008) Transplant Direct. 2016 Nov 18;2(12):e118. (PMID: 27990483) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (HMGB1 Protein) 0 (HMGB1 protein, human) |
| تواريخ الأحداث: | Date Created: 20210720 Date Completed: 20211028 Latest Revision: 20211028 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8306885 |
| DOI: | 10.12659/AOT.931625 |
| PMID: | 34282108 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2329-0358 |
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| DOI: | 10.12659/AOT.931625 |