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Brain vulnerability and viability after ischaemia.

التفاصيل البيبلوغرافية
العنوان: Brain vulnerability and viability after ischaemia.
المؤلفون: Daniele SG; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Medical Scientist Training Program (MD-PhD), Yale School of Medicine, New Haven, CT, USA., Trummer G; Department of Cardiovascular Surgery, University Hospital Freiburg, Medical Faculty of the Albert-Ludwigs-University Freiburg, Freiburg, Germany., Hossmann KA; Max Planck Institute for Metabolism Research, Cologne, Germany., Vrselja Z; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA., Benk C; Department of Cardiovascular Surgery, University Hospital Freiburg, Medical Faculty of the Albert-Ludwigs-University Freiburg, Freiburg, Germany., Gobeske KT; Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Damjanovic D; Department of Cardiovascular Surgery, University Hospital Freiburg, Medical Faculty of the Albert-Ludwigs-University Freiburg, Freiburg, Germany., Andrijevic D; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA., Pooth JS; Department of Cardiovascular Surgery, University Hospital Freiburg, Medical Faculty of the Albert-Ludwigs-University Freiburg, Freiburg, Germany., Dellal D; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Beyersdorf F; Department of Cardiovascular Surgery, University Hospital Freiburg, Medical Faculty of the Albert-Ludwigs-University Freiburg, Freiburg, Germany. friedhelm.beyersdorf@uniklinik-freiburg.de., Sestan N; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT, USA. nenad.sestan@yale.edu.; Yale Child Study Center, New Haven, CT, USA. nenad.sestan@yale.edu.
المصدر: Nature reviews. Neuroscience [Nat Rev Neurosci] 2021 Sep; Vol. 22 (9), pp. 553-572. Date of Electronic Publication: 2021 Jul 21.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0048 (Electronic) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat Rev Neurosci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Nature Pub. Group,
مواضيع طبية MeSH: Brain/*physiopathology , Brain Ischemia/*physiopathology , Cerebrovascular Circulation/*physiology , Neuroprotection/*physiology, Animals ; Humans
مستخلص: The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into question the temporal limits within which the brain is capable of tolerating prolonged circulatory arrest. This Review assesses cell type-specific mechanisms of global cerebral ischaemia, and examines the circumstances in which the brain exhibits heightened resilience to injury. We suggest strategies for expanding such discoveries to fuel translational research into novel cytoprotective therapies, and describe emerging technologies and experimental concepts. By doing so, we propose a new multimodal framework to investigate brain resuscitation following extended periods of circulatory arrest.
(© 2021. Springer Nature Limited.)
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تواريخ الأحداث: Date Created: 20210722 Date Completed: 20210927 Latest Revision: 20230206
رمز التحديث: 20240628
DOI: 10.1038/s41583-021-00488-y
PMID: 34290397
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-0048
DOI:10.1038/s41583-021-00488-y