دورية أكاديمية
The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial.
| العنوان: | The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial. |
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| المؤلفون: | Mokhtari MR; Department of Urology and Nephrology, Urmia University of Medical Sciences, Urmia, Iran. M.mokhtari@gmail.com., Farshid S; Department of Urology and Nephrology, Urmia University of Medical Sciences, Urmia, Iran. Saman.F@gmail.com., Modresi P; Department of Pathology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. dr.parisapatho@gmail.com., Abedi F; 3. Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Dr.f.abediurologist@gmail.com. |
| المصدر: | Urology journal [Urol J] 2021 Jul 22; Vol. 18 (6), pp. 608-611. Date of Electronic Publication: 2021 Jul 22. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Urology and Nephrology Research Center Country of Publication: Iran NLM ID: 101286676 Publication Model: Electronic Cited Medium: Internet ISSN: 1735-546X (Electronic) Linking ISSN: 17351308 NLM ISO Abbreviation: Urol J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tehran : Urology and Nephrology Research Center |
| مواضيع طبية MeSH: | Antifibrinolytic Agents*/therapeutic use , Nephrolithotomy, Percutaneous* , Tranexamic Acid*/therapeutic use, Blood Loss, Surgical/prevention & control ; Blood Transfusion ; Double-Blind Method ; Humans |
| مستخلص: | Purpose: Tranexamic acid is a fibrinolysis suppressor that is used for a variety of bleeding control procedures such as hematuria, surgery bleeding, and trauma caused bleeding. The advantages of using the tranexamic acid are bleeding control and less need for blood transfusion. Materials and Methods: This double blind clinical trial was conducted on 108 patients in Imam Khomeni Hospital, Urmia, Iran 2013-14. The control and intervention groups consisted of 54 randomly selected participants each. The intervention group received 1gr of intravenous tranexamic acid with initiation of surgery and 500mg orally each 8hrs afterwards up to three days. The control group received placebo capsules containing starch of the same form. Results: The mean term of hospitalization in the intervention group was significantly shorter than that of the control group (P<0.001). The difference between the two groups in terms of preoperative hemoglobin was not significant. However, the decrease in postoperative hemoglobin, intraoperative hemoglobin count in washing liquid, and hemoglobin count in the intervention group were significantly different from those of the control group (P<0.001). Conclusion: The findings showed that tranexamic acid decreased bleeding during PCNL and the need for blood transfusion. It also decreased the hospitalization term. |
| المشرفين على المادة: | 0 (Antifibrinolytic Agents) 6T84R30KC1 (Tranexamic Acid) |
| تواريخ الأحداث: | Date Created: 20210722 Date Completed: 20220119 Latest Revision: 20230812 |
| رمز التحديث: | 20230812 |
| DOI: | 10.22037/uj.v18i.6505 |
| PMID: | 34291443 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1735-546X |
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| DOI: | 10.22037/uj.v18i.6505 |