دورية أكاديمية
أعرض في EDS

Sepsis in patients hospitalized with coronavirus disease 2019: how often and how severe?

التفاصيل البيبلوغرافية
العنوان: Sepsis in patients hospitalized with coronavirus disease 2019: how often and how severe?
المؤلفون: da Silva Ramos FJ; Anesthesiology, Pain and Intensive Care Medicine Department, Federal University of São Paulo, São Paulo, Brazil., de Freitas FGR, Machado FR
المصدر: Current opinion in critical care [Curr Opin Crit Care] 2021 Oct 01; Vol. 27 (5), pp. 474-479.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9504454 Publication Model: Print Cited Medium: Internet ISSN: 1531-7072 (Electronic) Linking ISSN: 10705295 NLM ISO Abbreviation: Curr Opin Crit Care Subsets: MEDLINE
أسماء مطبوعة: Publication: <1999->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Philadelphia, PA : Current Science, c1995-
مواضيع طبية MeSH: COVID-19* , Sepsis*, Critical Illness ; Humans ; SARS-CoV-2
مستخلص: Purpose of Review: To discuss why severe COVID-19 should be considered sepsis and how co-infection and secondary infection can aggravate this condition and perpetuate organ dysfunction leading to high mortality rates.
Recent Findings: In severe COVID-19, there is both direct viral toxicity and dysregulated host response to infection. Although both coinfection and/or secondary infection are present, the latest is of greater concern mainly in resource-poor settings. Patients with severe COVID-19 present a phenotype of multiorgan dysfunction that leads to death in an unacceptable high percentage of the patients, with wide variability around the world. Similarly to endemic sepsis, the mortality of COVID-19 critically ill patients is higher in low-income and middle-income countries as compared with high-income countries. Disparities, including hospital strain, resources limitations, higher incidence of healthcare-associated infections (HAI), and staffing issues could in part explain this variability.
Summary: The high mortality rates of critically ill patients with severe COVID-19 disease are not only related to the severity of patient disease but also to modifiable factors, such as the ICU strain, HAI incidence, and organizational aspects. Therefore, HAI prevention and the delivery of best evidence-based care for these patients to avoid additional damage is important. Quality improvement interventions might help in improving outcomes mainly in resource-limited settings.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20210722 Date Completed: 20210906 Latest Revision: 20230913
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8452249
DOI: 10.1097/MCC.0000000000000861
PMID: 34292175
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-7072
DOI:10.1097/MCC.0000000000000861