دورية أكاديمية
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Acute toxicity and antimalarial studies of extract of  Allophylus spicatus in animals.

التفاصيل البيبلوغرافية
العنوان: Acute toxicity and antimalarial studies of extract of  Allophylus spicatus in animals.
المؤلفون: Adebayo AH; Department of Biochemistry, College of Science and Technology, Covenant University, Ogun State, PMB 1023, Canaan Land, Ota, Nigeria., Ishola TA; Department of Biochemistry, College of Science and Technology, Covenant University, Ogun State, PMB 1023, Canaan Land, Ota, Nigeria., Yakubu OF; Department of Biochemistry, College of Science and Technology, Covenant University, Ogun State, PMB 1023, Canaan Land, Ota, Nigeria.
المصدر: Toxicological research [Toxicol Res] 2021 Jan 09; Vol. 37 (3), pp. 345-354. Date of Electronic Publication: 2021 Jan 09 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101483324 Publication Model: eCollection Cited Medium: Print ISSN: 1976-8257 (Print) Linking ISSN: 19768257 NLM ISO Abbreviation: Toxicol Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2020- : Singapore : Springer Singapore
Original Publication: Seoul : Korean Society of Toxicology
مستخلص: Medicinal plants produce a variety of chemical substances with varied physiological effects. They are a huge reservoir of various chemical substances with potential therapeutic properties. Allophylus spicatus is a shrub that belong to  the Sapindaceae family. In this study, male  albino wistar rats (18) were used for acute toxicity test. Animals were divided into six groups of three rats each. Group A served as the control group while the other groups were dosed orally with 200, 500, 1000, 2000 and 5000 mg/kg body weight of extract and were observed for 14 days. Swiss albino mice (42) were used for the antimalarial study; five groups of six infected mice per group (Groups C-G) were respectively dosed orally with 25 mg chloroquine/kg bw, 200 mg of extract/kg bw, 400 mg/kg bw of extract, 25 mg chl./kg bw + 200 mg/kg bw of extract and 25 mg chl./kg bw + 400 mg/kg bw extract with three groups serving as the control (Groups A-C) for three days. Acute toxicity test and histology analysis on the liver tissue confirmed the safety of the extract at concentrations less than 1000 mg/kg b/w. Antimalarial studies showed the highest activity in the group administered with 400 mg/kg + 25 mg chl./kg b/w. In conclusion, A. spicatus was non-toxic at doses less than 1000 mg/kg and significantly reduced parasitemia count in P. berghei infected mice, thus validating its folkloric usage.
Supplementary Information: The online version contains supplementary material available at 10.1007/s43188-020-00070-1.
Competing Interests: Conflict of interestThe authors have no conflict of interest to disclose.
(© Korean Society of Toxicology 2021.)
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فهرسة مساهمة: Keywords: A. spicatus; Acute toxicity; Antimalarial; Malaria; Medicinal plants
تواريخ الأحداث: Date Created: 20210723 Latest Revision: 20220716
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8249555
DOI: 10.1007/s43188-020-00070-1
PMID: 34295798
قاعدة البيانات: MEDLINE
الوصف
تدمد:1976-8257
DOI:10.1007/s43188-020-00070-1