دورية أكاديمية
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Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model.

التفاصيل البيبلوغرافية
العنوان: Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model.
المؤلفون: Tai CC; Internal Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan., Lo HL; Department of Orthopedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan., Liaw CK; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhong He Dist., New Taipei City 23561, Taiwan.; Research Center of Biomedical Device, Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11301, Taiwan., Huang YM; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhong He Dist., New Taipei City 23561, Taiwan., Huang YH; Internal Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei 11031, Taiwan., Yang KY; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan., Huang CC; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan., Huang SI; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan., Shen HH; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan., Lin TH; Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan., Lu CK; Department of Orthopaedics, Park One International Hospital, Kaohsiung 813322, Taiwan., Liu WC; Department of Orthopedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.; Ph.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.; Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan., Sun JS; Department of Orthopedics, China Medical University, Taichung 40202, Taiwan.; School of Medicine, College of Medicine, China Medical University, Taichung 40202, Taiwan., Tsai PI; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan., Chen CY; Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Rd., Zhong He Dist., New Taipei City 23561, Taiwan.; Research Center of Biomedical Device, Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11301, Taiwan.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 08; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 08.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Absorbable Implants* , Biocompatible Materials*/chemistry , Biocompatible Materials*/toxicity , Suture Anchors*, Alanine Transaminase/blood ; Animals ; Biomechanical Phenomena ; Blood Urea Nitrogen ; Calcium Phosphates/chemistry ; Calcium Phosphates/toxicity ; Calcium Sulfate/administration & dosage ; Calcium Sulfate/chemistry ; Calcium Sulfate/toxicity ; Creatinine/blood ; Equipment Design ; Femur/diagnostic imaging ; Femur/ultrastructure ; Iron ; Lasers ; Materials Testing ; Microscopy, Electron, Scanning ; Molecular Structure ; Osseointegration ; Polymers/chemistry ; Polymers/toxicity ; Porosity ; Rabbits ; Random Allocation ; Tensile Strength ; Viscera ; X-Ray Microtomography
مستخلص: This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.
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معلومات مُعتمدة: 201956F0020; J356EX3200 Taipei Medical University-Shuang Ho Hospital; Industrial Technology Research Institute
فهرسة مساهمة: Keywords: additive manufacturing (3D printing); bioabsorbable; iron-based; suture anchor
المشرفين على المادة: 0 (Biocompatible Materials)
0 (Calcium Phosphates)
0 (Polymers)
0 (beta-tricalcium phosphate)
AYI8EX34EU (Creatinine)
E1UOL152H7 (Iron)
EC 2.6.1.2 (Alanine Transaminase)
WAT0DDB505 (Calcium Sulfate)
تواريخ الأحداث: Date Created: 20210724 Date Completed: 20210817 Latest Revision: 20210817
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8307211
DOI: 10.3390/ijms22147368
PMID: 34298988
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms22147368