دورية أكاديمية
Emergence of Nonlinear Mixed Selectivity in Prefrontal Cortex after Training.
| العنوان: | Emergence of Nonlinear Mixed Selectivity in Prefrontal Cortex after Training. |
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| المؤلفون: | Dang W; Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235., Jaffe RJ; Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157., Qi XL; Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157., Constantinidis C; Department of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157 Christos.Constantinidis.1@vanderbilt.edu.; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235.; Neuroscience Program, Vanderbilt University, Nashville, Tennessee 37235.; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Sep 01; Vol. 41 (35), pp. 7420-7434. Date of Electronic Publication: 2021 Jul 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Learning/*physiology , Memory, Short-Term/*physiology , Prefrontal Cortex/*physiology, Animals ; Macaca mulatta ; Male ; Neurons/physiology ; Nonlinear Dynamics ; Saccades/physiology ; Spatial Behavior/physiology |
| مستخلص: | Neurons in the PFC are typically activated by different cognitive tasks, and also by different stimuli and abstract variables within these tasks. A single neuron's selectivity for a given stimulus dimension often changes depending on its context, a phenomenon known as nonlinear mixed selectivity (NMS). It has previously been hypothesized that NMS emerges as a result of training to perform tasks in different contexts. We tested this hypothesis directly by examining the neuronal responses of different PFC areas before and after male monkeys were trained to perform different working memory tasks involving visual stimulus locations and/or shapes. We found that training induces a modest increase in the proportion of PFC neurons with NMS exclusively for spatial working memory, but not for shape working memory tasks, with area 9/46 undergoing the most significant increase in NMS cell proportion. We also found that increased working memory task complexity, in the form of simultaneously storing location and shape combinations, does not increase the degree of NMS for stimulus shape with other task variables. Lastly, in contrast to the previous studies, we did not find evidence that NMS is predictive of task performance. Our results thus provide critical insights on the representation of stimuli and task information in neuronal populations, in working memory. SIGNIFICANCE STATEMENT How multiple types of information are represented in working memory remains a complex computational problem. It has been hypothesized that nonlinear mixed selectivity allows neurons to efficiently encode multiple stimuli in different contexts, after subjects have been trained in complex tasks. Our analysis of prefrontal recordings obtained before and after training monkeys to perform working memory tasks only partially agreed with this prediction, in that nonlinear mixed selectivity emerged for spatial but not shape information, and mostly in mid-dorsal PFC. Nonlinear mixed selectivity also displayed little modulation across either task complexity or correct performance. These results point to other mechanisms, in addition to nonlinear mixed selectivity, representing complex information about stimulus and task context in neuronal activity. (Copyright © 2021 the authors.) |
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| معلومات مُعتمدة: | R01 EY017077 United States EY NEI NIH HHS |
| فهرسة مساهمة: | Keywords: monkey; neuron; neurophysiology; prefrontal cortex; working memory |
| تواريخ الأحداث: | Date Created: 20210724 Date Completed: 20211206 Latest Revision: 20220302 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8412986 |
| DOI: | 10.1523/JNEUROSCI.2814-20.2021 |
| PMID: | 34301827 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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| DOI: | 10.1523/JNEUROSCI.2814-20.2021 |