دورية أكاديمية

HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking.

التفاصيل البيبلوغرافية
العنوان: HIV-1 Hijacking of Host ATPases and GTPases That Control Protein Trafficking.
المؤلفون: Tavares LA; Department of Cell and Molecular Biology, Center for Virology Research, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Januário YC; Department of Cell and Molecular Biology, Center for Virology Research, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., daSilva LLP; Department of Cell and Molecular Biology, Center for Virology Research, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Jul 08; Vol. 9, pp. 622610. Date of Electronic Publication: 2021 Jul 08 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: The human immunodeficiency virus (HIV-1) modifies the host cell environment to ensure efficient and sustained viral replication. Key to these processes is the capacity of the virus to hijack ATPases, GTPases and the associated proteins that control intracellular protein trafficking. The functions of these energy-harnessing enzymes can be seized by HIV-1 to allow the intracellular transport of viral components within the host cell or to change the subcellular distribution of antiviral factors, leading to immune evasion. Here, we summarize how energy-related proteins deviate from their normal functions in host protein trafficking to aid the virus in different phases of its replicative cycle. Recent discoveries regarding the interplay among HIV-1 and host ATPases and GTPases may shed light on potential targets for pharmacological intervention.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Tavares, Januário and daSilva.)
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فهرسة مساهمة: Keywords: ATPases; GTPases; HIV-1; HIV-1 accessory proteins; HIV-1 pathogenesis; HIV-1 trafficking
تواريخ الأحداث: Date Created: 20210726 Latest Revision: 20210727
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8295591
DOI: 10.3389/fcell.2021.622610
PMID: 34307340
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-634X
DOI:10.3389/fcell.2021.622610