دورية أكاديمية
Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis.
| العنوان: | Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis. |
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| المؤلفون: | Abdelaleem OO; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Fouad NA; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Shaker OG; Department of Biochemistry and molecular biology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ahmed TI; Department of Internal medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Abdelghaffar NK; Department of clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Eid HM; Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mohamed AA; Department of Medical microbiology and immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Elebiary AM; Department of Medical physiology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Mohamed MM; Department of Internal medicine, Faculty of Medicine, Cairo University, Cairo, Egypt., Mahmoud RH; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. |
| المصدر: | International journal of clinical practice [Int J Clin Pract] 2021 Nov; Vol. 75 (11), pp. e14651. Date of Electronic Publication: 2021 Aug 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Country of Publication: India NLM ID: 9712381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-1241 (Electronic) Linking ISSN: 13685031 NLM ISO Abbreviation: Int J Clin Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Mumbai : Hindawi Original Publication: Esher [England] ; Bronxville, N.Y. : Medicom International, c1997- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid*/genetics , MicroRNAs*/genetics, Biomarkers ; Humans |
| مستخلص: | Background: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease which affects various tissues and organs mainly joints. Serum microRNAs are considered a new class of non-coding RNA which plays a vital role in pathogenesis of RA. Methods: The current study was conducted on 80 RA patients and 80 healthy participants. Serum expression levels of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 were evaluated via real-time quantitative polymerase chain reaction (PCR). Results: Significant upregulation of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 was reported in the present study with respect to the control group (P = .031, P = .017, P = .026, P = .036 and P = .05, respectively). Furthermore, significant positive correlation between the abovementioned microRNAs with DAS28 score (P < .001, each) was demonstrated. Conclusion: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR-483-5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. (© 2021 John Wiley & Sons Ltd.) |
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| المشرفين على المادة: | 0 (Biomarkers) 0 (MIRN224 microRNA, human) 0 (MIRN375 microRNA, human) 0 (MIRN378 microRNA, human) 0 (MIRN483 microRNA, human) 0 (MIRN760 microRNA, human) 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20210726 Date Completed: 20211022 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/ijcp.14651 |
| PMID: | 34310809 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1742-1241 |
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| DOI: | 10.1111/ijcp.14651 |