دورية أكاديمية
أعرض في EDS

Acute encephalitis, myoclonus and Sweet syndrome after mRNA-1273 vaccine.

التفاصيل البيبلوغرافية
العنوان: Acute encephalitis, myoclonus and Sweet syndrome after mRNA-1273 vaccine.
المؤلفون: Torrealba-Acosta G; Neurology, Baylor College of Medicine, Houston, Texas, USA gabriel.torrealbaacosta@bcm.edu., Martin JC; Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA., Huttenbach Y; Department of Dermatopathology, Baylor College of Medicine, Houston, Texas, USA., Garcia CR; Neurology, Baylor College of Medicine, Houston, Texas, USA., Sohail MR; Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA., Agarwal SK; Department of Medicine, Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas, USA., Wasko C; Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA., Bershad EM; Neurology, Baylor College of Medicine, Houston, Texas, USA., Hirzallah MI; Neurology, Baylor College of Medicine, Houston, Texas, USA.
المصدر: BMJ case reports [BMJ Case Rep] 2021 Jul 26; Vol. 14 (7). Date of Electronic Publication: 2021 Jul 26.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Pub. Group
مواضيع طبية MeSH: Encephalitis*/diagnosis , Encephalitis*/etiology , Myoclonus*/etiology , Sweet Syndrome*/diagnosis , Sweet Syndrome*/drug therapy , Sweet Syndrome*/etiology, 2019-nCoV Vaccine mRNA-1273 ; COVID-19 Vaccines ; Humans
مستخلص: A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
References: Cutan Ocul Toxicol. 2013 Sep;32(3):260-1. (PMID: 23351017)
N Engl J Med. 2020 Oct 15;383(16):1544-1555. (PMID: 32722908)
N Engl J Med. 2020 Nov 12;383(20):1920-1931. (PMID: 32663912)
J Am Acad Dermatol. 2018 Dec;79(6):987-1006. (PMID: 29653210)
Postgrad Med. 2011 Sep;123(5):194-204. (PMID: 21904102)
N Engl J Med. 2021 Apr 1;384(13):1273-1277. (PMID: 33657292)
Vaccine. 2007 Aug 1;25(31):5771-92. (PMID: 17570566)
N Engl J Med. 2020 Dec 17;383(25):2427-2438. (PMID: 32991794)
F1000Res. 2020 Jan 29;9:. (PMID: 32047620)
Eur J Pharmacol. 2021 Feb 5;892:173751. (PMID: 33245898)
Parkinsonism Relat Disord. 2009 Dec;15(10):792-4. (PMID: 19447066)
BMJ. 2020 Mar 12;368:m1036. (PMID: 32165426)
Parkinsonism Relat Disord. 2000 Oct 1;6(4):241-242. (PMID: 10900400)
J Eur Acad Dermatol Venereol. 2020 Oct;34(10):e534-e535. (PMID: 32452542)
Vaccine. 2014 Nov 20;32(49):6676-82. (PMID: 24837504)
N Engl J Med. 2021 Feb 4;384(5):403-416. (PMID: 33378609)
Lancet Infect Dis. 2020 May;20(5):533-534. (PMID: 32087114)
فهرسة مساهمة: Keywords: COVID-19; dermatology; neurology; unwanted effects / adverse reactions; vaccination/immunisation
المشرفين على المادة: 0 (COVID-19 Vaccines)
EPK39PL4R4 (2019-nCoV Vaccine mRNA-1273)
تواريخ الأحداث: Date Created: 20210727 Date Completed: 20210728 Latest Revision: 20211204
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8314742
DOI: 10.1136/bcr-2021-243173
PMID: 34312136
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-790X
DOI:10.1136/bcr-2021-243173