دورية أكاديمية
أعرض في EDS

Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.

التفاصيل البيبلوغرافية
العنوان: Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.
المؤلفون: Springer LE; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Patton JB; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Zhan T; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Rabson AB; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America., Lin HC; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America., Manser T; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Lok JB; Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Hess JA; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Abraham D; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jul 27; Vol. 15 (7), pp. e0009559. Date of Electronic Publication: 2021 Jul 27 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Antigens, CD34/*blood , Cytokines/*metabolism , HTLV-I Infections/*immunology , Hematopoietic Stem Cells/*metabolism , Strongyloides stercoralis/*growth & development , Strongyloidiasis/*immunology, Animals ; Cell Line ; Coinfection ; Cytokines/genetics ; Fetal Blood ; HTLV-I Infections/complications ; Human T-lymphotropic virus 1 ; Larva/growth & development ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Strongyloidiasis/complications
مستخلص: Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. stercoralis infection induces a Th2 response. However, coinfection with the two pathogens has been associated with the development of S. stercoralis hyperinfection and an alteration of the Th1/Th2 balance. In this study, a model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established. An increased level of mortality was observed in the HTLV-1 and coinfected animals when compared to the S. stercoralis infected group. The mortality was not correlated with proviral loads or total viral RNA. Analysis of cytokine profiles showed a distinct shift towards Th1 responses in HTLV-1 infected animals, a shift towards Th2 cytokines in S. stercoralis infected animals and elevated TNF-α responses in coinfected animals. HTLV-1 infected and coinfection groups showed a significant, yet non-clonal expansion of the CD4+CD25+ T-cell population. Numbers of worms in the coinfection group did not differ from those of the S. stercoralis infected group and no autoinfective larvae were found. However, infective larvae recovered from the coinfection group showed an enhancement in growth, as was seen in mice with S. stercoralis hyperinfection caused by treatment with steroids. Humanized mice coinfected with S. stercoralis and HTLV-1 demonstrate features associated with human infection with these pathogens and provide a unique opportunity to study the interaction between these two infections in vivo in the context of human immune cells.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: R01 AI050668 United States AI NIAID NIH HHS; R21 AI105856 United States AI NIAID NIH HHS; R21 AI144572 United States AI NIAID NIH HHS; R33 AI105856 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Antigens, CD34)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20210727 Date Completed: 20211026 Latest Revision: 20220406
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8315519
DOI: 10.1371/journal.pntd.0009559
PMID: 34314415
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0009559