دورية أكاديمية
Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.
العنوان: | Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth. |
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المؤلفون: | Springer LE; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Patton JB; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Zhan T; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Rabson AB; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America., Lin HC; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America., Manser T; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Lok JB; Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Hess JA; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America., Abraham D; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America. |
المصدر: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jul 27; Vol. 15 (7), pp. e0009559. Date of Electronic Publication: 2021 Jul 27 (Print Publication: 2021). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
مواضيع طبية MeSH: | Antigens, CD34/*blood , Cytokines/*metabolism , HTLV-I Infections/*immunology , Hematopoietic Stem Cells/*metabolism , Strongyloides stercoralis/*growth & development , Strongyloidiasis/*immunology, Animals ; Cell Line ; Coinfection ; Cytokines/genetics ; Fetal Blood ; HTLV-I Infections/complications ; Human T-lymphotropic virus 1 ; Larva/growth & development ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Strongyloidiasis/complications |
مستخلص: | Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of coinfection. Independently, HTLV-1 induces a Th1 response and S. stercoralis infection induces a Th2 response. However, coinfection with the two pathogens has been associated with the development of S. stercoralis hyperinfection and an alteration of the Th1/Th2 balance. In this study, a model of HTLV-1 and S. stercoralis coinfection in CD34+ umbilical cord blood hematopoietic stem cell engrafted humanized mice was established. An increased level of mortality was observed in the HTLV-1 and coinfected animals when compared to the S. stercoralis infected group. The mortality was not correlated with proviral loads or total viral RNA. Analysis of cytokine profiles showed a distinct shift towards Th1 responses in HTLV-1 infected animals, a shift towards Th2 cytokines in S. stercoralis infected animals and elevated TNF-α responses in coinfected animals. HTLV-1 infected and coinfection groups showed a significant, yet non-clonal expansion of the CD4+CD25+ T-cell population. Numbers of worms in the coinfection group did not differ from those of the S. stercoralis infected group and no autoinfective larvae were found. However, infective larvae recovered from the coinfection group showed an enhancement in growth, as was seen in mice with S. stercoralis hyperinfection caused by treatment with steroids. Humanized mice coinfected with S. stercoralis and HTLV-1 demonstrate features associated with human infection with these pathogens and provide a unique opportunity to study the interaction between these two infections in vivo in the context of human immune cells. Competing Interests: The authors have declared that no competing interests exist. |
References: | Mediators Inflamm. 2013;2013:434010. (PMID: 23533306) Exp Parasitol. 1984 Jun;57(3):287-96. (PMID: 6723900) Acta Haematol. 2011;126(2):63-7. (PMID: 21474923) PLoS Negl Trop Dis. 2013 May 09;7(5):e2214. (PMID: 23675546) J Clin Invest. 2014 Aug;124(8):3431-42. (PMID: 24960164) PLoS Negl Trop Dis. 2019 Jun 6;13(6):e0007415. (PMID: 31170141) Blood. 1991 Jul 1;78(1):192-6. (PMID: 1648975) Nat Genet. 2015 Nov;47(11):1304-15. (PMID: 26437031) Retrovirology. 2012 May 30;9:46. (PMID: 22647666) J Clin Virol. 2013 Oct;58(2):494-6. (PMID: 23911677) Front Immunol. 2019 Jun 26;10:1427. (PMID: 31297113) Viruses. 2017 Dec 21;10(1):. (PMID: 29267225) Viruses. 2011 Sep;3(9):1532-48. (PMID: 21994794) BMJ. 2013 Jul 30;347:f4610. (PMID: 23900531) Clin Microbiol Rev. 2010 Jul;23(3):577-89. (PMID: 20610824) J Immunol. 2012 Jan 1;188(1):417-25. (PMID: 22131328) Infect Dis Clin North Am. 2019 Mar;33(1):135-151. (PMID: 30712758) PLoS Negl Trop Dis. 2013 Jul 11;7(7):e2288. (PMID: 23875033) PLoS Pathog. 2013;9(10):e1003708. (PMID: 24130499) Trans R Soc Trop Med Hyg. 2013 Aug;107(8):526-9. (PMID: 23843560) J Parasit Dis. 2019 Jun;43(2):167-175. (PMID: 31263320) Immunology. 2009 Sep;128(1 Suppl):e777-86. (PMID: 19740339) Dtsch Med Wochenschr. 2005 Apr 22;130(16):1007-10. (PMID: 15830313) PLoS Negl Trop Dis. 2009 Jun 09;3(6):e456. (PMID: 19513105) J Virol. 2019 Sep 12;93(19):. (PMID: 31315992) Oncogene. 2002 Apr 11;21(16):2466-75. (PMID: 11971181) Int J Cancer. 2009 Aug 1;125(3):737-8. (PMID: 19437534) PLoS Pathog. 2013;9(4):e1003263. (PMID: 23592987) Front Microbiol. 2012 Nov 15;3:388. (PMID: 23162541) Presse Med. 2002 Jun 22;31(22):1021-3. (PMID: 12148255) J Neuroimmunol. 2017 Mar 15;304:51-55. (PMID: 27542993) Semin Cancer Biol. 2014 Jun;26:89-98. (PMID: 24316494) BMC Immunol. 2017 Feb 3;18(1):7. (PMID: 28158970) Am J Clin Pathol. 1997 Jan;107(1):81-7. (PMID: 8980372) Mod Rheumatol. 2015 Sep;25(5):794-7. (PMID: 24252020) J Immunol. 2005 May 15;174(10):6477-89. (PMID: 15879151) Science. 2014 Aug 1;345(6196):578-82. (PMID: 25082704) Jpn J Clin Oncol. 1985 Jun;15(2):423-30. (PMID: 2991627) Biom J. 2008 Jun;50(3):346-63. (PMID: 18481363) Science. 2014 Aug 1;345(6196):573-7. (PMID: 24968940) J Leukoc Biol. 2009 Aug;86(2):219-27. (PMID: 19369639) Oncogene. 2000 Oct 12;19(43):4954-60. (PMID: 11042682) Oncogene. 2005 Sep 5;24(39):6058-68. (PMID: 16155612) J Immunol. 2015 Sep 1;195(5):2241-50. (PMID: 26202988) Blood. 2011 Mar 17;117(11):3113-22. (PMID: 21228324) Iran J Basic Med Sci. 2013 Mar;16(3):208-12. (PMID: 24470863) Parasite Immunol. 2004 Nov-Dec;26(11-12):487-97. (PMID: 15771684) Blood. 2002 Jan 1;99(1):88-94. (PMID: 11756157) Gan. 1981 Dec;72(6):978-81. (PMID: 6281119) J Virol. 2006 Nov;80(21):10683-91. (PMID: 16943297) J Immunol. 1995 Jan 1;154(1):180-91. (PMID: 7995938) Gastroenterol Hepatol (N Y). 2011 Mar;7(3):194-6. (PMID: 21528049) J Med Virol. 2015 Dec;87(12):2130-4. (PMID: 25982784) J Clin Rheumatol. 2007 Jun;13(3):150-2. (PMID: 17551383) Parasite Immunol. 2001 Sep;23(9):503-7. (PMID: 11589779) Crit Rev Immunol. 1998;18(4):275-303. (PMID: 9704191) J Neurovirol. 1998 Dec;4(6):586-93. (PMID: 10065900) Blood. 2010 Aug 26;116(8):1211-9. (PMID: 20448111) J Neuroimmune Pharmacol. 2017 Sep;12(3):504-520. (PMID: 28374110) Clin Mol Allergy. 2006 May 30;4:8. (PMID: 16734908) PLoS Biol. 2010 Oct 19;8(10):e1000525. (PMID: 20976099) Pathogens. 2020 Oct 29;9(11):. (PMID: 33137906) Joint Bone Spine. 2014 Jul;81(4):360-1. (PMID: 24289962) J Infect Dis. 2005 Feb 15;191(4):612-8. (PMID: 15655786) PLoS Pathog. 2010 Apr 29;6(4):e1000892. (PMID: 20442785) Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):204-209. (PMID: 29203662) Blood. 2014 Jan 16;123(3):346-55. (PMID: 24196073) Parasitol Int. 2020 Jun;76:102092. (PMID: 32120049) |
معلومات مُعتمدة: | R01 AI050668 United States AI NIAID NIH HHS; R21 AI105856 United States AI NIAID NIH HHS; R21 AI144572 United States AI NIAID NIH HHS; R33 AI105856 United States AI NIAID NIH HHS |
المشرفين على المادة: | 0 (Antigens, CD34) 0 (Cytokines) |
تواريخ الأحداث: | Date Created: 20210727 Date Completed: 20211026 Latest Revision: 20220406 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8315519 |
DOI: | 10.1371/journal.pntd.0009559 |
PMID: | 34314415 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1935-2735 |
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DOI: | 10.1371/journal.pntd.0009559 |