دورية أكاديمية
Imidazolidine Derivatives in Cancer Research: What is known?
| العنوان: | Imidazolidine Derivatives in Cancer Research: What is known? |
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| المؤلفون: | da Silva Júnior AA; Department of Therapeutic innovation, Federal University of Pernambuco, Recife, Brazil., da Rocha Pitta MG; Department of Therapeutic innovation, Federal University of Pernambuco, Recife, Brazil., de Oliveira Chagas MB; Life Science Center, Federal University of Pernambuco, Caruaru, Brazil., de Melo Rêgo MJB; Department of Biochemistry, Federal University of Pernambuco, Recife- 50730 120, Brazil., da Rosa MM; Department of Biochemistry, Federal University of Pernambuco, Recife- 50730 120, Brazil., da Rocha Pitta MG; Department of Biochemistry, Federal University of Pernambuco, Recife- 50730 120, Brazil. |
| المصدر: | Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2022; Vol. 22 (7), pp. 1272-1277. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Bentham Science Publishers Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, [2006]- |
| مواضيع طبية MeSH: | Imidazolidines*/metabolism , Imidazolidines*/pharmacology , Imidazolidines*/therapeutic use , Neoplasms*/drug therapy , Neoplasms*/pathology, DNA/metabolism ; Humans |
| مستخلص: | It is well known that cancer is the second leading cause of death worldwide. Due to this fact, new results for the treatment of cancer are constantly being introduced and verified. Imidazolidine derivatives regulate cell cycle progression and DNA stability. Structurally, a heterocyclic nucleus favors a direct DNA interaction and therefore, control of the DNA replication process. This review aims not only to discuss the role of imidazolidines in cancer therapy but also explore the functionality of such agents in the future aspects of cancer prognosis and treatment. Convincing data from 1996 to 2021 has presented imidazolidine derivatives as a relevant therapeutic tool to modulate cancer progression and malignancy. Here we highlight these aspects in a variety of cell lines, cancer types, involving in vitro and in vivo techniques. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Apoptosis; DNA; anticancer; cancer; cell cycle; imidazolidine |
| المشرفين على المادة: | 0 (Imidazolidines) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20210728 Date Completed: 20220510 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1871520621666210727113639 |
| PMID: | 34315391 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-5992 |
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| DOI: | 10.2174/1871520621666210727113639 |