تقرير
أعرض في EDS

Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma.

التفاصيل البيبلوغرافية
العنوان: Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma.
المؤلفون: Ohmura S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Li J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany., Jabar S; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany., Ranft A; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany., Vinca E; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany., Ceranski K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany., Carreño-Gonzalez MJ; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany., Romero-Pérez L; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Musa J; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany., Bestvater F; Light Microscopy Facility, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Münster, Germany., Dirksen U; Pediatrics III, West German Cancer Centre, University Hospital Essen, Essen, Germany.; German Cancer Consortium (DKTK), partner site Essen, Essen, Germany., Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany., Cidre-Aranaz F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Grünewald TGP; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.; Division of Translational Pediatric Sarcoma Research (B410), German Cancer Research Center (DKFZ) & Hopp-Children's Cancer Center (KiTZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. t.gruenewald@kitz-heidelberg.de.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. t.gruenewald@kitz-heidelberg.de.
المصدر: Molecular cancer [Mol Cancer] 2021 Jul 27; Vol. 20 (1), pp. 97. Date of Electronic Publication: 2021 Jul 27.
نوع المنشور: Letter; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2002-
مواضيع طبية MeSH: Biomarkers, Tumor*, Bone Neoplasms/*etiology , Ribonucleoside Diphosphate Reductase/*genetics , Sarcoma, Ewing/*etiology, Animals ; Bone Neoplasms/diagnosis ; Bone Neoplasms/therapy ; Disease Management ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Molecular Targeted Therapy ; Prognosis ; Pyridines/pharmacology ; Ribonucleoside Diphosphate Reductase/metabolism ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/mortality ; Sarcoma, Ewing/therapy ; Thiosemicarbazones/pharmacology ; Xenograft Model Antitumor Assays
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فهرسة مساهمة: Keywords: Chemoresistance; Ewing sarcoma; Paediatric oncology; Prognostic biomarker; RRM2; Targeted therapy; Triapine
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Pyridines)
0 (Thiosemicarbazones)
143621-35-6 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone)
EC 1.17.4.- (ribonucleotide reductase M2)
EC 1.17.4.1 (Ribonucleoside Diphosphate Reductase)
تواريخ الأحداث: Date Created: 20210728 Date Completed: 20220124 Latest Revision: 20220124
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8314608
DOI: 10.1186/s12943-021-01393-9
PMID: 34315482
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4598
DOI:10.1186/s12943-021-01393-9