دورية أكاديمية
Activation of cAMP-dependent phosphorylation pathways is independent of ROS production during mouse sperm capacitation.
| العنوان: | Activation of cAMP-dependent phosphorylation pathways is independent of ROS production during mouse sperm capacitation. |
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| المؤلفون: | Takei GL; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA., Tourzani DA; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA., Paudel B; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA., Visconti PE; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA. |
| المصدر: | Molecular reproduction and development [Mol Reprod Dev] 2021 Aug; Vol. 88 (8), pp. 544-557. Date of Electronic Publication: 2021 Jul 27. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8903333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2795 (Electronic) Linking ISSN: 1040452X NLM ISO Abbreviation: Mol Reprod Dev Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, N.J. : Wiley-Liss Original Publication: New York, NY : A.R. Liss, 1988- |
| مواضيع طبية MeSH: | Cyclic AMP/*metabolism , Cyclic AMP-Dependent Protein Kinases/*metabolism , Reactive Oxygen Species/*metabolism , Signal Transduction/*physiology , Sperm Capacitation/*physiology , Spermatozoa/*metabolism, Animals ; Calcium/metabolism ; Catalase/metabolism ; Male ; Mice ; Phosphorylation ; Superoxide Dismutase/metabolism |
| مستخلص: | Mammalian sperm have to undergo capacitation to fertilize the egg. At the molecular level, capacitation involves cAMP synthesis, protein kinase A activation, and downstream increase in tyrosine phosphorylation. In addition, during capacitation, mammalian sperm actively generate reactive oxygen species (ROS). It has been proposed that ROS modulate phosphorylation pathways; however, the crosstalk between these signaling processes is not well-understood. In the present study, we used loss- and gain-of-function approaches to evaluate the interconnection between ROS and phosphorylation. We showed that BSA and HCO (© 2021 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | T32 GM108556 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: ROS; capacitation; catalase; phosphorylation; sperm |
| المشرفين على المادة: | 0 (Reactive Oxygen Species) E0399OZS9N (Cyclic AMP) EC 1.11.1.6 (Catalase) EC 1.15.1.1 (Superoxide Dismutase) EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20210728 Date Completed: 20220121 Latest Revision: 20220121 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/mrd.23524 |
| PMID: | 34318548 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-2795 |
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| DOI: | 10.1002/mrd.23524 |