دورية أكاديمية
Anti-nociceptive Effects of Dexmedetomidine Infusion Plus Modified Intercostal Nerve Block During Single-port Thoracoscopic Lobectomy: A Double-blind, Randomized Controlled Trial.
| العنوان: | Anti-nociceptive Effects of Dexmedetomidine Infusion Plus Modified Intercostal Nerve Block During Single-port Thoracoscopic Lobectomy: A Double-blind, Randomized Controlled Trial. |
|---|---|
| المؤلفون: | Cheng XQ; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China., Cheng J; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Zhou YN; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China., Zuo YM; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China., Liu XS; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China., Gu EW; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China., Xu GH; Department of Anesthesiology, First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China. |
| المصدر: | Pain physician [Pain Physician] 2021 Aug; Vol. 24 (5), pp. E565-E572. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Interventional Pain Physicians Country of Publication: United States NLM ID: 100954394 Publication Model: Print Cited Medium: Internet ISSN: 2150-1149 (Electronic) Linking ISSN: 15333159 NLM ISO Abbreviation: Pain Physician Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paducah, Ky. : American Society of Interventional Pain Physicians Original Publication: Paducah, Ky. : Association of Pain Management Anesthesiologists |
| مواضيع طبية MeSH: | Dexmedetomidine*, Double-Blind Method ; Humans ; Intercostal Nerves ; Pain, Postoperative/drug therapy ; Remifentanil |
| مستخلص: | Background: Multimodal general anesthesia based on modified intercostal nerve block (MINB) has been found as a novel method to achieve an intraoperative opioid-sparing effect. However, there is little information about the effective method to inhibit visceral nociceptive stress during single-port thoracoscopic surgery. Objective: To investigate whether a low-dose dexmedetomidine infusion followed by MINB might be an alternative method to blunt visceral stress effectively. Study Design: Double-blind, randomized control trial. Setting: Affiliated hospital from March 2020 through September 2020. Methods: Fifty-four patients were randomized (1:1), 45 patients were included to receive dexmedetomidine with a 0.4 microgram/kg bolus followed by 0.4 microgram/kg/h infusion (group Dex) or saline placebo (group Con). During the operation, an additional dose of remifentanil 0.05-0.25 microgram/kg/min was used to keep mean arterial pressure (MAP) or heart rate (HR) values around 20% below baseline values. The primary outcome was to evaluate remifentanil consumption. Secondary outcomes included intraoperative hemodynamics, the first time to press an analgesia pump, and adverse effects. Results: Remifentanil consumption during surgery was markedly decreased in the Dex group than in the Con group (0 [0-0] versus 560.0 [337.5-965.0] microgram; P = 0.00). MAP and HR in the Con group during the first 5 minutes after visceral exploration was significantly higher than in the Dex group (P < 0.05). Time to first opioid demand was significantly prolonged (P = 0.04) and postoperative length of stay was shortened slightly in the Dex group (P = 0.05). Limitations: This study was limited by the measurement of nociception. Conclusions: This study demonstrates that low-dose dexmedetomidine infusion combined with MINB might be an effective alternative method to blunt visceral stress in patients undergoing single-port thoracoscopic lobectomy. Furthermore, the analgesic effect of MINB was significantly prolonged after dexmedetomidine infusion. |
| فهرسة مساهمة: | Keywords: dexmedetomidine; nociceptive stress; remifentanil; Opioid-sparing |
| سلسلة جزيئية: | ChiCTR ChiCTR2000030959 |
| المشرفين على المادة: | 67VB76HONO (Dexmedetomidine) P10582JYYK (Remifentanil) |
| تواريخ الأحداث: | Date Created: 20210729 Date Completed: 20211124 Latest Revision: 20211124 |
| رمز التحديث: | 20231215 |
| PMID: | 34323443 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2150-1149 |
|---|