دورية أكاديمية
Disrupting cortico-cerebellar communication impairs dexterity.
العنوان: | Disrupting cortico-cerebellar communication impairs dexterity. |
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المؤلفون: | Guo JZ; Janelia Research Campus, Ashburn, United States., Sauerbrei BA; Janelia Research Campus, Ashburn, United States., Cohen JD; Janelia Research Campus, Ashburn, United States., Mischiati M; Janelia Research Campus, Ashburn, United States., Graves AR; Johns Hopkins University, Baltimore, United States., Pisanello F; Italian Institute of Technology, Genoa, Italy., Branson KM; Janelia Research Campus, Ashburn, United States., Hantman AW; Janelia Research Campus, Ashburn, United States. |
المصدر: | ELife [Elife] 2021 Jul 29; Vol. 10. Date of Electronic Publication: 2021 Jul 29. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Neural Pathways*, Cerebellar Nuclei/*physiology , Motor Cortex/*physiology , Movement/*physiology, Animals ; Mice ; Mice, Transgenic ; Optogenetics |
مستخلص: | To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous system, but it has been challenging to identify the roles of cortical projections to specific targets. Here, we selectively disrupt cortico-cerebellar communication in the mouse by optogenetically stimulating the pontine nuclei in a cued reaching task. This perturbation did not typically block movement initiation, but degraded the precision, accuracy, duration, or success rate of the movement. Correspondingly, cerebellar and cortical activity during movement were largely preserved, but differences in hand velocity between control and stimulation conditions predicted from neural activity were correlated with observed velocity differences. These results suggest that while the total output of motor cortex drives reaching, the cortico-cerebellar loop makes small adjustments that contribute to the successful execution of this dexterous movement. Competing Interests: JG, BS, JC, MM, AG, FP, KB, AH No competing interests declared (© 2021, Guo et al.) |
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معلومات مُعتمدة: | United States HHMI Howard Hughes Medical Institute |
فهرسة مساهمة: | Keywords: cerebellum; dexterity; motor cortex; mouse; neural dynamics; neuroscience; pontine nuclei; reaching |
سلسلة جزيئية: | Dryad 10.5061/dryad.mgqnk990f |
تواريخ الأحداث: | Date Created: 20210729 Date Completed: 20211012 Latest Revision: 20240403 |
رمز التحديث: | 20240403 |
مُعرف محوري في PubMed: | PMC8321550 |
DOI: | 10.7554/eLife.65906 |
PMID: | 34324417 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.65906 |