دورية أكاديمية
أعرض في EDS

Disrupting cortico-cerebellar communication impairs dexterity.

التفاصيل البيبلوغرافية
العنوان: Disrupting cortico-cerebellar communication impairs dexterity.
المؤلفون: Guo JZ; Janelia Research Campus, Ashburn, United States., Sauerbrei BA; Janelia Research Campus, Ashburn, United States., Cohen JD; Janelia Research Campus, Ashburn, United States., Mischiati M; Janelia Research Campus, Ashburn, United States., Graves AR; Johns Hopkins University, Baltimore, United States., Pisanello F; Italian Institute of Technology, Genoa, Italy., Branson KM; Janelia Research Campus, Ashburn, United States., Hantman AW; Janelia Research Campus, Ashburn, United States.
المصدر: ELife [Elife] 2021 Jul 29; Vol. 10. Date of Electronic Publication: 2021 Jul 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Neural Pathways*, Cerebellar Nuclei/*physiology , Motor Cortex/*physiology , Movement/*physiology, Animals ; Mice ; Mice, Transgenic ; Optogenetics
مستخلص: To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous system, but it has been challenging to identify the roles of cortical projections to specific targets. Here, we selectively disrupt cortico-cerebellar communication in the mouse by optogenetically stimulating the pontine nuclei in a cued reaching task. This perturbation did not typically block movement initiation, but degraded the precision, accuracy, duration, or success rate of the movement. Correspondingly, cerebellar and cortical activity during movement were largely preserved, but differences in hand velocity between control and stimulation conditions predicted from neural activity were correlated with observed velocity differences. These results suggest that while the total output of motor cortex drives reaching, the cortico-cerebellar loop makes small adjustments that contribute to the successful execution of this dexterous movement.
Competing Interests: JG, BS, JC, MM, AG, FP, KB, AH No competing interests declared
(© 2021, Guo et al.)
References: J Neurophysiol. 1993 Apr;69(4):1136-49. (PMID: 8492153)
J Neurophysiol. 1977 Sep;40(5):1038-50. (PMID: 409807)
Neuron. 2019 Jul 17;103(2):335-348.e5. (PMID: 31174960)
Brain Res. 1972 Feb 25;37(2):173-85. (PMID: 5061111)
Nature. 2017 Nov 8;551(7679):232-236. (PMID: 29120427)
J Comp Neurol. 1946 Feb;84:31-118. (PMID: 21019911)
Elife. 2013 Feb 26;2:e00400. (PMID: 23467508)
J Neurophysiol. 1989 Jul;62(1):198-211. (PMID: 2754472)
Brain. 2004 Jun;127(Pt 6):1269-91. (PMID: 15128614)
Neurosci Res. 1992 Mar;13(2):83-118. (PMID: 1374872)
Brain Res. 1975 Aug 29;94(2):237-51. (PMID: 807298)
J Neurophysiol. 2000 Apr;83(4):1886-99. (PMID: 10758100)
Brain. 1983 Sep;106 (Pt 3):675-705. (PMID: 6640276)
Neuron. 2017 Aug 2;95(3):683-696.e11. (PMID: 28735748)
J Neurophysiol. 2000 Jul;84(1):585-90. (PMID: 10899231)
Brain Res Bull. 1986 Aug;17(2):169-79. (PMID: 2429739)
Nat Neurosci. 2016 Apr;19(4):554-6. (PMID: 26950004)
Cell Rep. 2018 Feb 27;22(9):2322-2333. (PMID: 29490269)
J Comp Neurol. 1989 Aug 22;286(4):427-41. (PMID: 2778100)
Neurosci Res. 1987 Dec;5(2):140-56. (PMID: 3431754)
Cell Rep. 2020 May 12;31(6):107595. (PMID: 32402292)
Cell Rep. 2019 May 28;27(9):2608-2619.e4. (PMID: 31141686)
Elife. 2015 Dec 02;4:e10774. (PMID: 26633811)
Cell. 2019 Sep 19;179(1):268-281.e13. (PMID: 31495573)
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7595-600. (PMID: 21504945)
Physiol Rev. 1992 Oct;72(4):967-1017. (PMID: 1438583)
Neuroscience. 1988 Apr;25(1):27-45. (PMID: 3393281)
Behav Brain Res. 1986 Sep;21(3):167-81. (PMID: 3768133)
Cell Rep. 2018 May 1;23(5):1275-1285. (PMID: 29719244)
J Neurophysiol. 1998 Feb;79(2):537-54. (PMID: 9463420)
J Neurophysiol. 1973 Nov;36(6):974-95. (PMID: 4202614)
Nature. 2020 Jan;577(7790):386-391. (PMID: 31875851)
Cell. 2019 Apr 18;177(3):669-682.e24. (PMID: 30929904)
J Comp Neurol. 2004 Oct 18;478(3):306-22. (PMID: 15368533)
Brain. 2001 Mar;124(Pt 3):571-86. (PMID: 11222457)
Nat Neurosci. 2014 Oct;17(10):1395-403. (PMID: 25174005)
Elife. 2021 Jul 29;10:. (PMID: 34324417)
J Neurophysiol. 1974 Jul;37(4):792-804. (PMID: 4209702)
J Comp Neurol. 1985 Jul 8;237(2):251-63. (PMID: 4031124)
Nat Neurosci. 2018 Sep;21(9):1281-1289. (PMID: 30127430)
Brain. 1968 Mar;91(1):1-14. (PMID: 4966862)
Brain Res. 1975 Aug 29;94(2):219-36. (PMID: 807297)
J Neurosci. 2017 Oct 18;37(42):10085-10096. (PMID: 28916520)
Cell Rep. 2018 Mar 6;22(10):2767-2783. (PMID: 29514103)
Nature. 2011 Dec 25;481(7382):502-5. (PMID: 22198670)
Nature. 2018 Nov;563(7729):113-116. (PMID: 30333626)
J Neurosci. 2012 Apr 25;32(17):5990-9. (PMID: 22539859)
Nat Neurosci. 2017 Aug;20(8):1180-1188. (PMID: 28628101)
J Neurophysiol. 2000 Oct;84(4):1781-9. (PMID: 11024070)
Neuron. 2013 Dec 18;80(6):1368-83. (PMID: 24360541)
Science. 2019 Apr 19;364(6437):255. (PMID: 31000656)
J Neurosci. 2009 May 13;29(19):6154-66. (PMID: 19439593)
معلومات مُعتمدة: United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: cerebellum; dexterity; motor cortex; mouse; neural dynamics; neuroscience; pontine nuclei; reaching
سلسلة جزيئية: Dryad 10.5061/dryad.mgqnk990f
تواريخ الأحداث: Date Created: 20210729 Date Completed: 20211012 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8321550
DOI: 10.7554/eLife.65906
PMID: 34324417
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.65906