دورية أكاديمية
Lychnophora pinaster's effects on inflammation and pain in acute gout.
| العنوان: | Lychnophora pinaster's effects on inflammation and pain in acute gout. |
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| المؤلفون: | Barros CH; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Matosinhos RC; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Bernardes ACFPF; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Araújo MCPM; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Bezerra JP; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Sachs D; Instituto de Física e Química, Universidade Federal de Itajubá, Itajubá, Minas Gerais, Brazil., Soares RDOA; Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Saúde-Guimarães DA; Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic address: saude@ufop.edu.br. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2021 Nov 15; Vol. 280, pp. 114460. Date of Electronic Publication: 2021 Jul 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Arthritis, Gouty/*drug therapy , Asteraceae/*chemistry , Gout/*drug therapy , Plant Extracts/*pharmacology, Analgesics/chemistry ; Analgesics/isolation & purification ; Analgesics/pharmacology ; Animals ; Arthritis, Gouty/pathology ; Brazil ; Disease Models, Animal ; Gout/pathology ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Pain/drug therapy ; Pain/etiology ; Plant Extracts/chemistry |
| مستخلص: | Ethnopharmacological Relevance: Ethanolic extract of aerial parts from Lychnophora pinaster Mart. are used in traditional Brazilian medicine for treating pain, rheumatism and inflammation. Aim of the Study: Drugs for the treatment of gout present severe adverse effects, justifying the need to search for new therapeutic options. The aim of the present study was to evaluate the effects of the ethanolic extract of L. pinaster and its main constituents in arthritis induced in mice by the injection of monosodium urate (MSU) crystals. Materials and Methods: Antinociceptive effect was investigated using an electronic pressure-meter nociception paw test in C57BL/6 mice. Anti-gouty arthritis was investigated in mice induced with gout by the injection of MSU crystals into their femur-tibial tissue. Ethanolic extract of the aerial parts of Lychnophora pinaster and its main chemical constituents were evaluated as treatment. Results: The ethanolic extract and their main chemical constituents inhibited neutrophil migration, reduced IL-1β and TNF-α concentrations in the inflamed tissue and showed antinociceptive activity. Conclusions: Gouty arthritis effects of the ethanolic extract can be attached to a synergistic effect of terpenes, flavonoids and phenolic acids present in the extract. Results obtained support the use of this extract and its main chemical constituents in the treatment of gout, inflammation, and pain. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cytokines; Gout; Inflammation; Lychnophora pinaster; Neutrophil; Nociception |
| المشرفين على المادة: | 0 (Analgesics) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20210729 Date Completed: 20220117 Latest Revision: 20220117 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2021.114460 |
| PMID: | 34324952 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2021.114460 |