دورية أكاديمية
Extracellular matrix remodeling precedes atrial fibrillation: Results of the PREDICT-AF trial.
| العنوان: | Extracellular matrix remodeling precedes atrial fibrillation: Results of the PREDICT-AF trial. |
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| المؤلفون: | van den Berg NWE; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Neefs J; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kawasaki M; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Nariswari FA; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Wesselink R; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Fabrizi B; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Jongejan A; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Klaver MN; Department of Cardiology and Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands., Havenaar H; Department of Cardiology and Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands., Hulsman EL; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Wintgens LIS; Department of Cardiology and Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands., Baalman SWE; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Meulendijks ER; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., van Boven WJ; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., de Jong JSSG; Department of Cardiology, OLVG, Amsterdam, The Netherlands., van Putte BP; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Cardiology and Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands., Driessen AHG; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Boersma LVA; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; Department of Cardiology and Cardiothoracic Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands., de Groot JR; Department of Clinical and Experimental Cardiology and Cardiothoracic Surgery, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: j.r.degroot@amsterdamumc.nl. |
| مؤلفون مشاركون: | PREDICT-AF Investigators |
| المصدر: | Heart rhythm [Heart Rhythm] 2021 Dec; Vol. 18 (12), pp. 2115-2125. Date of Electronic Publication: 2021 Jul 29. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101200317 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-3871 (Electronic) Linking ISSN: 15475271 NLM ISO Abbreviation: Heart Rhythm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, c2004- |
| مواضيع طبية MeSH: | Atrial Appendage*/pathology , Atrial Appendage*/surgery , Atrial Fibrillation*/blood , Atrial Fibrillation*/diagnosis , Atrial Fibrillation*/prevention & control , Extracellular Matrix*/metabolism , Extracellular Matrix*/pathology , Heart Atria*/pathology , Heart Atria*/physiopathology, Atrial Remodeling/*physiology, Aged ; Biglycan/metabolism ; Biomarkers/analysis ; Biomarkers/blood ; Cardiac Surgical Procedures/methods ; Collagen/metabolism ; Electrocardiography, Ambulatory/methods ; Electrocardiography, Ambulatory/statistics & numerical data ; Female ; Humans ; Male ; Predictive Value of Tests ; Prognosis ; Prophylactic Surgical Procedures/methods ; Tenascin/metabolism ; Thrombospondins/metabolism |
| مستخلص: | Background: To which extent atrial remodeling occurs before atrial fibrillation (AF) is unknown. Objective: The PREventive left atrial appenDage resection for the predICtion of fuTure Atrial Fibrillation (PREDICT-AF) study investigated such subclinical remodeling, which may be used for risk stratification and AF prevention. Methods: Patients (N = 150) without a history of AF with a CHA Results: Eighteen patients (12%) developed incident AF, which was associated with increased tissue gene expression of collagen I (COL1A1), collagen III (COL3A1), and collagen VIII (COL8A2), tenascin-C (TNC), thrombospondin-2 (THBS2), and biglycan (BGN). Furthermore, the fibroblast activating endothelin-1 (EDN1) and sodium voltage-gated channel β subunit 2 (SCN2B) were associated with incident AF whereas the Kir2.1 channel (KCNJ2) tended to downregulate. The plasma levels of COL8A2 and TNC correlated with tissue expression and predicted incident AF. A gene panel including tissue KCNJ2, COL1A1, COL8A2, and EDN1 outperformed clinical prediction models in discriminating incident AF. Conclusion: The PREDICT-AF study demonstrates that atrial remodeling occurs long before incident AF and implies future potential for early patient identification and therapies to prevent AF (ClinicalTrials.gov identifier NCT03130985). (Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Heart Rhythm. 2021 Dec;18(12):2126-2127. (PMID: 34508877) |
| فهرسة مساهمة: | Keywords: Atrial fibrillation; Atrial remodeling; Biomarkers; Collagen VIII; Extracellular matrix; Tenascin |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03130985 |
| المشرفين على المادة: | 0 (BGN protein, human) 0 (Biglycan) 0 (Biomarkers) 0 (TNC protein, human) 0 (Tenascin) 0 (Thrombospondins) 0 (thrombospondin 2) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20210731 Date Completed: 20220303 Latest Revision: 20220303 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.hrthm.2021.07.059 |
| PMID: | 34332113 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1556-3871 |
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| DOI: | 10.1016/j.hrthm.2021.07.059 |