دورية أكاديمية
Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action.
| العنوان: | Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action. |
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| المؤلفون: | Carvalho MTB; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil., Araújo-Filho HG; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil., Barreto AS; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil; Laboratory Pharmacology Cardiovascular (LAFAC), Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, Brazil., Quintans-Júnior LJ; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil., Quintans JSS; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil., Barreto RSS; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address: rosanasbarreto@pq.cnpq.br. |
| المصدر: | Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Sep; Vol. 90, pp. 153636. Date of Electronic Publication: 2021 Jun 19. |
| نوع المنشور: | Journal Article; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Urban & Fischer Verlag Original Publication: Stuttgart ; New York : G. Fischer, c1994- |
| مواضيع طبية MeSH: | Flavonoids*/pharmacology , Wound Healing*, Animals ; Cytokines ; Endothelial Cells ; Fibroblasts ; Macrophages ; Signal Transduction |
| مستخلص: | Background: Flavonoids are a class of compounds with a wide variety of biological functions, being an important source of new products with pharmaceutical potential, including treatment of skin wounds. Purpose: This review aimed to summarize and evaluate the evidence in the literature in respect of the healing properties of flavonoids on skin wounds in animal models. Study Design: This is a systematic review following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Methods: This was carried out through a specialized search of four databases: PubMed, Scopus, Web of Science and Embase. The following keyword combinations were used: "flavonoidal" OR "flavonoid" OR "flavonoidic" OR "flavonoids" AND "wound healing" as well as MeSH terms, Emtree terms and free-text words. Results: Fifty-five (55) articles met the established inclusion and exclusion criteria. Flavonoids presented effects in respect of the inflammatory process, angiogenesis, re-epithelialization and oxidative stress. They were shown to be able to act on macrophages, fibroblasts and endothelial cells by mediating the release and expression of TGF-β1, VEGF, Ang, Tie, Smad 2 and 3, and IL-10. Moreover, they were able to reduce the release of inflammatory cytokines, NFκB, ROS and the M1 phenotype. Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways. Conclusion: Flavonoids are useful tools in the development of therapies to treat skin lesions, and our review provides a scientific basis for future basic and translational research. (Copyright © 2021. Published by Elsevier GmbH.) |
| فهرسة مساهمة: | Keywords: Chronic wounds; Flavonoids; Natural products; Skin lesions; Wound healing |
| المشرفين على المادة: | 0 (Cytokines) 0 (Flavonoids) |
| تواريخ الأحداث: | Date Created: 20210801 Date Completed: 20210929 Latest Revision: 20210929 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.phymed.2021.153636 |
| PMID: | 34333340 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-095X |
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| DOI: | 10.1016/j.phymed.2021.153636 |