دورية أكاديمية
أعرض في EDS

Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis.

التفاصيل البيبلوغرافية
العنوان: Behavior of Iron and Ferritin After Bariatric Surgery in Patients With and Without Hepatic Steatosis.
المؤلفون: da Costa Leite Junior G; Departamento de Ciências da Vida, Universidade do Estado da Bahia - UNEB, Rua Silveira Martins, 2555, Cabula, Salvador, BA, CEP: 41.150-000, Brazil., Lacerda MD; Faculdade de Tecnologia e Ciências - UNIFTC, Salvador, BA, Brazil., Alencar TALB; Faculdade de Tecnologia e Ciências - UNIFTC, Salvador, BA, Brazil., Café M; IMC Obesity Center, Hospital Aliança, Salvador, BA, Brazil., Giuffrida FMA; Departamento de Ciências da Vida, Universidade do Estado da Bahia - UNEB, Rua Silveira Martins, 2555, Cabula, Salvador, BA, CEP: 41.150-000, Brazil. fgiuffrida@uneb.br.
المصدر: Obesity surgery [Obes Surg] 2021 Nov; Vol. 31 (11), pp. 4761-4766. Date of Electronic Publication: 2021 Aug 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : New York : Springer Science + Business Media
Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991-
مواضيع طبية MeSH: Bariatric Surgery* , Gastric Bypass* , Obesity, Morbid*/surgery, Ferritins ; Humans ; Iron
مستخلص: Background: Iron deficiency and hepatic steatosis are common in bariatric surgery patients. Steatosis can falsely elevate ferritin values even in presence of iron deficiency. This study aims to assess the influence of hepatic steatosis on iron deficiency and replacement therapy after bariatric surgery.
Methods: Seventy-nine individuals undergoing gastric bypass have been studied at 4 time points (preoperative and 1, 3, and 6 months after surgery). Weight, body mass index (BMI), iron, ferritin, vitamin B12, folate, hemoglobin, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and use of iron replacement were recorded.
Results: Forty-two individuals (53%) had moderate/severe steatosis assessed by ultrasound. No differences were seen in iron profile and replacement therapy features compared to individuals with no/mild steatosis both in the preoperative and postoperative periods. Mixed model analysis showed ferritin levels to be higher in the moderate/severe steatosis group than in no/mild steatosis at the 6th month (139 ± 131 vs. 60.9 ± 49.8, p < 0.05). Values in both groups were lower than baseline, with p < 0.0001. The same was observed with serum iron (92.1 ± 39.6 moderate/severe steatosis vs. 68.6 ± 33.4 no/mild steatosis, p < 0.001; p from baseline < 0.01 for both). GGT was higher in moderate/severe steatosis in the 3rd month (38.8 ± 40.5 vs. 28.8 ± 20.8, p < 0.05; p from baseline < 0.0001 for both).
Conclusions: Ferritin levels were consistently higher in individuals with steatosis in the follow-up of bariatric surgery, but no apparent implication on the diagnosis of iron deficiency and in the prescription of replacement therapy was demonstrated at 6 months of follow-up. Longer studies are probably necessary to investigate this matter.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Anemia; Bariatric surgery; Ferritin; Iron; Obesity; Steatosis
المشرفين على المادة: 9007-73-2 (Ferritins)
E1UOL152H7 (Iron)
تواريخ الأحداث: Date Created: 20210803 Date Completed: 20211025 Latest Revision: 20211025
رمز التحديث: 20231215
DOI: 10.1007/s11695-021-05629-x
PMID: 34341911
قاعدة البيانات: MEDLINE
الوصف
تدمد:1708-0428
DOI:10.1007/s11695-021-05629-x