دورية أكاديمية
Charles Bonnet syndrome in patients with Stargardt disease: prevalence and risk factors.
| العنوان: | Charles Bonnet syndrome in patients with Stargardt disease: prevalence and risk factors. |
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| المؤلفون: | Dhooge PPA; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands.; Donders Insitute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands., Teunisse RJ; Department of Old Age Psychiatry, GGNet Network for Mental Health Care in East Gelderland and Zutphen, Warnsveld, The Netherlands., Liefers B; Diagnostic Image Analysis Group, Department of Radiology, Radboudumc, Nijmegen, The Netherlands., Lambertus S; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands., Bax NM; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands., Hoyng CB; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands., Cruysberg JRM; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands., Klevering BJ; Department of Ophthalmology, Radboudumc, Nijmegen, The Netherlands jeroen.klevering@radboudumc.nl. |
| المصدر: | The British journal of ophthalmology [Br J Ophthalmol] 2023 Feb; Vol. 107 (2), pp. 248-253. Date of Electronic Publication: 2021 Aug 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 1992- : London : BMJ Pub. Group Original Publication: 1917-Dec. 1991: London : British Medical Association |
| مواضيع طبية MeSH: | Charles Bonnet Syndrome*/complications, Humans ; Female ; Male ; Stargardt Disease ; Prevalence ; Hallucinations/diagnosis ; Hallucinations/epidemiology ; Hallucinations/complications ; Risk Factors ; Vision Disorders/diagnosis ; Vision Disorders/epidemiology |
| مستخلص: | Aims: To describe the prevalence of the Charles Bonnet syndrome (CBS) and search for potential CBS risk factors in a Dutch Stargardt disease (STGD1) cohort. Methods: Eighty-three patients with STGD1 were screened for CBS. They underwent a full eye examination. All patients completed the social functioning domain of the 36-Item Short Form Health Survey questionnaire. Participants suspected of CBS were interviewed to further evaluate their visual hallucinations. Results: CBS prevalence was 8.4%. Six out of seven patients with CBS were women. CBS was not associated with age (p=0.279, Mann-Whitney). Patients with CBS had a significant lower social functioning score (p<0.05, Mann-Whitney). All seven patients with CBS were in the category of vision impairment (visual acuity <6/12, but ≥3/60). Moreover, first hallucinations manifested after a drop in visual acuity. The retinal atrophic area of the worst eye tended to be lower in the CBS group (range 0.11-9.86 mm 2 ) as compared with controls (range 0-180 mm 2 ). There was no relation between the position of the scotoma and the location of the visual hallucinations. Conclusion: The relative high CBS prevalence in STGD1 suggests that CBS may be more prevalent in younger ophthalmic patients than currently presumed. In this specific group of patients, we established social isolation and acquired vision impairment as risk factors for CBS. There was a female preponderance among patients with CBS. Age and retinal pigment epithelium atrophy were not identified as significant risk factors. We should actively diagnose CBS in patients of any age who fulfil the criteria for the category vision impairment, especially in cases where social isolation is suspected. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.) |
| فهرسة مساهمة: | Keywords: dystrophy; macula; retina; visual perception |
| تواريخ الأحداث: | Date Created: 20210805 Date Completed: 20230124 Latest Revision: 20230201 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1136/bjophthalmol-2021-319525 |
| PMID: | 34348923 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2079 |
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| DOI: | 10.1136/bjophthalmol-2021-319525 |