دورية أكاديمية
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.
| العنوان: | Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy. |
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| المؤلفون: | Ippolito MR; Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy., Martis V; Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy., Martin S; Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy., Tijhuis AE; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands., Hong C; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands., Wardenaar R; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands., Dumont M; Institut Curie, PSL Research University, CNRS, UMR144, Paris, France., Zerbib J; Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Spierings DCJ; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands., Fachinetti D; Institut Curie, PSL Research University, CNRS, UMR144, Paris, France., Ben-David U; Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands., Santaguida S; Department of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Via Santa Sofia 9/1, 20122 Milan, Italy. Electronic address: stefano.santaguida@ieo.it. |
| المصدر: | Developmental cell [Dev Cell] 2021 Sep 13; Vol. 56 (17), pp. 2440-2454.e6. Date of Electronic Publication: 2021 Aug 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2001- |
| مواضيع طبية MeSH: | Aneuploidy* , Drug Therapy*/methods, Chromosomal Instability/*genetics , Drug Resistance/*genetics , Gene Dosage/*genetics, Genomic Instability/genetics ; Humans ; Karyotype |
| مستخلص: | Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells might exploit aneuploidy-induced genome instability and the resulting gene copy-number changes to survive under conditions of selective pressure, such as chemotherapy. Resistance to chemotherapeutic drugs was dictated by the acquisition of recurrent karyotypes, indicating that gene dosage might play a role in driving chemoresistance. Thus, our study establishes a causal link between aneuploidy-driven changes in gene copy number and chemoresistance and might explain why some chemotherapies fail to succeed. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Dev Cell. 2021 Sep 13;56(17):2399-2400. (PMID: 34520761) |
| فهرسة مساهمة: | Keywords: aneuploidy; cancer; chemotherapy; drug resistance; genome instability |
| تواريخ الأحداث: | Date Created: 20210805 Date Completed: 20211126 Latest Revision: 20211126 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.devcel.2021.07.006 |
| PMID: | 34352223 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-1551 |
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| DOI: | 10.1016/j.devcel.2021.07.006 |