دورية أكاديمية
أعرض في EDS

Optic disc edema and chorioretinal folds develop during strict 6° head-down tilt bed rest with or without artificial gravity.

التفاصيل البيبلوغرافية
العنوان: Optic disc edema and chorioretinal folds develop during strict 6° head-down tilt bed rest with or without artificial gravity.
المؤلفون: Laurie SS; KBR, Houston, TX, USA., Greenwald SH; KBR, Houston, TX, USA., Marshall-Goebel K; KBR, Houston, TX, USA., Pardon LP; KBR, Houston, TX, USA., Gupta A; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA., Lee SMC; KBR, Houston, TX, USA., Stern C; Institute of Aerospace Medicine, German Aerospace Center, Clinical Aerospace Medicine, Cologne, Germany., Sangi-Haghpeykar H; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA., Macias BR; NASA Johnson Space Center, Houston, TX, USA., Bershad EM; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.; Department of Neurology, Baylor College of Medicine, Houston, TX, USA.; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
المصدر: Physiological reports [Physiol Rep] 2021 Aug; Vol. 9 (15), pp. e14977.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: Bed Rest/*adverse effects , Choroid Diseases/*pathology , Head-Down Tilt/*adverse effects , Papilledema/*pathology , Retinal Diseases/*pathology , Weightlessness Simulation/*adverse effects, Adult ; Case-Control Studies ; Choroid Diseases/etiology ; Female ; Humans ; Male ; Papilledema/etiology ; Retinal Diseases/etiology
مستخلص: Spaceflight associated neuro-ocular syndrome (SANS) is hypothesized to develop as a consequence of the chronic headward fluid shift that occurs in sustained weightlessness. We exposed healthy subjects (n = 24) to strict 6° head-down tilt bed rest (HDTBR), an analog of weightlessness that generates a sustained headward fluid shift, and we monitored for ocular changes similar to findings that develop in SANS. Two-thirds of the subjects received a daily 30-min exposure to artificial gravity (AG, 1 g at center of mass, ~0.3 g at eye level) during HDTBR by either continuous (cAG, n = 8) or intermittent (iAG, n = 8) short-arm centrifugation to investigate whether this intervention would attenuate headward fluid shift-induced ocular changes. Optical coherence tomography images were acquired to quantify changes in peripapillary total retinal thickness (TRT), retinal nerve fiber layer thickness, and choroidal thickness, and to detect chorioretinal folds. Intraocular pressure (IOP), optical biometry, and standard automated perimetry data were collected. TRT increased by 35.9 µm (95% CI, 19.9-51.9 µm, p < 0.0001), 36.5 µm (95% CI, 4.7-68.2 µm, p = 0.01), and 27.6 µm (95% CI, 8.8-46.3 µm, p = 0.0005) at HDTBR day 58 in the control, cAG, and iAG groups, respectively. Chorioretinal folds developed in six subjects across the groups, despite small increases in IOP. Visual function outcomes did not change. These findings validate strict HDTBR without elevated ambient CO 2 as a model for investigating SANS and suggest that a fluid shift reversal of longer duration and/or greater magnitude at the eye may be required to prevent or mitigate SANS.
(© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.)
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فهرسة مساهمة: Keywords: artificial gravity; bed rest; centrifugation; chorioretinal folds; retinal thickness; spaceflight analog; spaceflight associated neuro-ocular syndrome
تواريخ الأحداث: Date Created: 20210806 Date Completed: 20220228 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8343460
DOI: 10.14814/phy2.14977
PMID: 34355874
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.14977