دورية أكاديمية
Postprandial concentration of circulating branched chain amino acids are able to predict the carbohydrate content of the ingested mixed meal.
| العنوان: | Postprandial concentration of circulating branched chain amino acids are able to predict the carbohydrate content of the ingested mixed meal. |
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| المؤلفون: | Hagve M; Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA. Electronic address: m.hagve@ctral.org., Simbo SY; Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA. Electronic address: sy.simbo@ctral.org., Ruebush LE; Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA. Electronic address: le.ruebush@ctral.org., Engelen MPKJ; Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA. Electronic address: mpkj.engelen@ctral.org., Gutierrez-Osuna R; Department of Computer Science & Engineering, Texas A&M University, College Station, TX, USA. Electronic address: rgutier@tamu.edu., Mortazavi BJ; Department of Computer Science & Engineering, Texas A&M University, College Station, TX, USA. Electronic address: bobakm@tamu.edu., Cote GL; Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA. Electronic address: gcote@tamu.edu., Deutz NEP; Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA. Electronic address: nep.deutz@ctral.org. |
| المصدر: | Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 Aug; Vol. 40 (8), pp. 5020-5029. Date of Electronic Publication: 2021 Jul 19. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982- |
| مواضيع طبية MeSH: | Postprandial Period*, Amino Acids, Branched-Chain/*blood , Dietary Carbohydrates/*blood , Meals/*physiology, Aged ; Amino Acids/blood ; Blood Glucose/analysis ; Dietary Fats/blood ; Dietary Proteins/blood ; Eating/physiology ; Female ; Healthy Volunteers ; Humans ; Insulin/blood ; Male ; Predictive Value of Tests ; Triglycerides/blood |
| مستخلص: | Background: The amount of the macronutrients protein and carbohydrate (CHO) in a mixed meal is known to affect each other's digestion, absorption, and subsequent metabolism. While the effect of the amount of dietary protein and fat on the glycemic response is well studied, the ability of postprandial plasma amino acid patterns to predict the meal composition is unknown. Objective: To study the postprandial plasma amino acid patterns in relation to the protein, CHO, and fat content of different mixed meals and to investigate if these patterns can predict the macronutrient meal composition. Design: Ten older adults were given 9 meals with 3 different levels (low, medium, and high) of protein, CHO, and fat in different combinations, taking the medium content as that of a standardized western meal. We monitored the postprandial plasma response for amino acids, glucose, insulin, and triglycerides for 8 h and the areas under the curve (AUC) were subsequently calculated. Multiple regression analysis was performed to determine if amino acid patterns could predict the meal composition. Results: Increasing meal CHO content reduced the postprandial plasma response of several amino acids including all branched chain amino acids (BCAA) (leucine; q < 0.0001, isoleucine; q = 0.0035, valine; q = 0.0022). The plasma BCAA patterns after the meal significantly predicted the meal's CHO content (leucine; p < 0.0001, isoleucine; p = 0.0003, valine; p = 0.0008) along with aspartate (p < 0.0001), tyrosine (p < 0.0001), methionine (p = 0.0159) and phenylalanine (p = 0.0332). Plasma citrulline predicted best the fat content of the meal (p = 0.0024). Conclusions: The postprandial plasma BCAA patterns are lower with increasing meal CHO content and are strong predictors of a mixed meal protein and CHO composition, as are plasma citrulline for the fat content. We hypothesize that postprandial plasma amino acid concentrations can be used to predict the meal's macronutrient composition. Competing Interests: Conflict of interest The authors declare no conflict of interest. (Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amino acid; Macronutrients; Metabolic monitoring; Mixed meals; Prediction |
| المشرفين على المادة: | 0 (Amino Acids) 0 (Amino Acids, Branched-Chain) 0 (Blood Glucose) 0 (Dietary Carbohydrates) 0 (Dietary Fats) 0 (Dietary Proteins) 0 (Insulin) 0 (Triglycerides) |
| تواريخ الأحداث: | Date Created: 20210808 Date Completed: 20211227 Latest Revision: 20211227 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clnu.2021.07.016 |
| PMID: | 34365036 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1983 |
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| DOI: | 10.1016/j.clnu.2021.07.016 |